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Interpretation:
To give the explanation whether the acid-catalyzed hydrolysis of acetamide is a reversible or irreversible reaction.
Concept introduction:
In acid hydrolysis of amide, acid protonates carbonyl oxygen of amide which increases the electrophilicity of the carbonyl carbon. Water acts as a nucleophile gets attached to the carbonyl carbon of amide to form tetrahedral intermediate(A) which on losing proton get converted to tetrahedral intermediate(B). The nitrogen of tetrahedral intermediate (B) gets protonated to form tetrahedral intermediate(C). The
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Chapter 15 Solutions
EBK ORGANIC CHEMISTRY
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- What is the difference between the aminolysis of an ester and that of an acyl halide?arrow_forwardClick the "draw structure" button to activate the drawing utility. Some penicillins cannot be administered orally because their B-lactam is rapidly hydrolyzed by the acidic environment of the stomach. Draw the product that forms in the following hydrolysis reaction. H H R. H3O+ -N- но HINarrow_forwardDescribe the Concept of Acid-Catalyzed Ester Hydrolysis and Transesterification.arrow_forward
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