Concept explainers
To explain: The effect of introducing a mutation in a gene that codes for an RTK lacking extracellular domain.
Introduction: Receptor tyrosine kinase (RTK) has two domains: an extracellular domain to which the ligand binds to and an intracellular kinase domain that dimerizes upon ligand binding, thus activating the kinase part of the domain. Mutation to any domain leads to malfunctioning of the receptor.
To explain: The effect of introducing a mutation in a gene that codes for an RTK lacking intracellular domain.
Introduction: Receptor tyrosine kinase (RTK) has two domains: an extracellular domain to which the ligand binds to and an intracellular kinase domain that dimerizes upon ligand binding, thus activating the kinase part of the domain. Mutation to any domain leads to malfunctioning of the receptor.
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