Essential Cell Biology
Essential Cell Biology
4th Edition
ISBN: 9780815344544
Author: Keith Roberts, Karen Hopkin, Alexander D Johnson, Martin Raff, Dennis Bray, Bruce Alberts, Julian Lewis, Peter Walter
Publisher: TAYLOR
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Chapter 16, Problem 21Q
Summary Introduction

To explain: The consequences of ryanodine calcium channels present in the sarcoplasmic reticulum. Unlike IP3 opened channels, these are opened by the binding of calcium itself.

Concept introduction: Sarcoplasmic reticulum is a special type of endoplasmic reticulum found in the muscle cells. They have more number of calcium channels than normal. PL C cleaves the phosphatidyl inositol to generate secondary messengers: inositol triphosphate (IP3) and diacylglycerol (DAG). IP3 then opens the Ca2+ ion channels present on the membrane of the endoplasmic reticulum (ER).The above is the case of normal ER. In the case of muscle cells where troponin is present, there is a requirement of higher amount of Ca2+ ions, as it has high affinity for it and large number of calcium ions are required for muscle contraction signaling. So, a special type of calcium channel called ryanodine channel is present. Ryanodine channel is opened by the presence of calcium ions itself.

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