Concept explainers
Introduction:
ABO blood grouping was first discovered by Carl Landsteiner. This system is used to denote the presence of one, both, or neither of the A and B antigens on erythrocytes. In a humantransfusion, it is the most important of the 36 classification systems. A mismatched transfusion can cause serious potentially fatal adverse reactions. If an individual receives a mismatched transfusion of red blood cells with different antigens, it causes a transfusion reaction resulting in clumping, when antibodies bind to those cells. These cells are destroyed by releasing hemoglobin in the bloodstream, thus blocking blood vessels kidneys and other body organs.
Table: ABO Blood group antigens present on RBC and IgM antibodies present in serum
GROUP A | GROUP B | GROUP AB | GROUP O | |
RED BLOOD CELL TYPE | A | B | AB | O |
Antibodies in plasma | Anti-B | Anti-A | NONE | Anti-A and Anti-B |
Antigens in RBC | A antigen | B antigen | A and B antigens | none |
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Chapter 17 Solutions
NESTER'S MICROBIOLOGY-ACCESS
- The figure above depicts an antibody. For the labeled areas, which statement among A-D is not correct? A) O Mature, functional IgA antibodies possess a total of two sites labeled A B) O Your IgM antibodies are all similar in these areas: A C) O During opsonization, area B would bind to a bacterium D) O Your IgD antibodies are all different in this area: B 111 E) O None are matched correctly. B.arrow_forwardWhich of the following is one of the family of immunoglobin like proteins that mediate Ca+2?a) N-CAMb) Integrinc) Cadherind) Selectinarrow_forwardWhat are the monoclonal antibodies: a) antibodies produced in one animal; b) antibodies delivered in one vial; c) antibodies produced by single immunization; d) antibodies recognizing the same antigenarrow_forward
- 1. Which of the following white blood cells would you expect to find in high numbers during a helminth infection but not during a bacterial infection? Hint: don't forget that helminths are eukaryotes.... a) Macrophages b) Mast Cells c) Neutrophils d) Eosinophil 2.Which of the following properly describe Major Histocompatability Complex (MHC)? a) Directed selection creates complexity and differences between cells in the same individual b) Inheritance makes it identical for all siblings that share the same parents c) Natural selection has made it identical for all members of the same species d)Random selection creates variety between individual humans. Give the answer of both question.arrow_forwardT cells can differentiate into 5 different subsets of helper T cells. Answer the following questions for TH1 cells: A) In general, list three unique factors that differentiate the TH1 subset from the other subsets. B) For each of those factors identified in A, provide one specific example that applies to TH1 cells. C) What type of pathogens are targeted by the TH1 cells?arrow_forwardIn a blood transfusion, if the donor and recipient blood types are not matched correctly, it may result in a: a) Type I hypersensitivity reaction O b) Type II hypersensitivity reaction c) Type III hypersensitivity reaction d) Type IV hypersensitivity reactionarrow_forward
- 1.The passing of antibodies into newborn babies by their mothers is known as: A) active immunity B) passive immunity C) primary immune response D) antigens The immune system responds to the antigens found on invading microorganisms by: A) producing antibodies B) antibodies preventing the microbe from causing infection C) marking the microbe so that it can be attacked by white blood cells D) all the abovearrow_forward41) For the successful development of a vaccine to be used against a pathogen, it is necessary that A) the surface antigens of the pathogen do not change. B) a rearrangement of the B cell receptor antibodies takes place. C) all of the surface antigens on the pathogen be identified. D) the pathogen has only one epitope. E) the MHC molecules are heterozygous. 42) In the human disease known as lupus, there is an immune reaction against a patient's own DNA from broken or dying cells, which categorizes lupus as A) an allergy. B) an immunodeficiency. C) an autoimmune disease. D) an antigenic variation. E) a cancer.arrow_forwardWhich antibody type description among A- D is falsely characterized? A) O IgA: form dimers; prevent adherence of pathogens to mucosal surfaces 1f1 B) O IgG: circulating antibody with multiple functions; formed in high numbers in secondary antibody response C) O IgM: forms multimers whose function is agglutination of infectious microbes D) O IgE, IgD: carry out their function while bound to the surfaces of specific cell types E) O None are false, A-D are all correctarrow_forward
- . A) What is the significance of producing monoclonal antibodies? B) What is the role of cell culture in production of monoclonal antibodies? C) Name and briefly explain the use of any 4 commercially available monoclonal antibodies.arrow_forwardWhich of the following statements about white blood cells is TRUE? A) Lymphocytes are agranular white blood cells whose primary function is phagocytosis B) Neutrophils are granular white blood cells whose primary function is phagocytic C) Monocytes are divided into B-monocytes & T-monocytes D) Both B & C E) All of the abovearrow_forwardOne very effective treatment for SARS-Cov-2 is the injection of serum containing antibodies from recovered patients into the blood stream of infected, symptomatic, non-recovered individuals. This type of treatment is an example of: A) innate immunity B) naturally acquired active immunity C) naturally acquired passive immunity D) artificially acquired active immunity E) artificially acquired passive immunityarrow_forward
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