ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260406092
Author: HARTWELL, Leland, HOOD, Leroy, Goldberg, Michael
Publisher: Mcgraw-hill Education/stony Brook University
expand_more
expand_more
format_list_bulleted
Textbook Question
Chapter 17, Problem 40P
Researchers know that Fru-M controls male sexual behavior in Drosophila because inappropriate Fru-M expression in females causes them to behave like males: Such females display male behaviors that are oriented toward other females.
a. | Describe a fru mutation that could cause the expression of Fru-M in females. |
b. | Describe a transgene construct that scientists could generate and insert into Drosophila females that would have the same effect as the mutant you described in (a). |
Expert Solution & Answer
![Check Mark](/static/check-mark.png)
Want to see the full answer?
Check out a sample textbook solution![Blurred answer](/static/blurred-answer.jpg)
Students have asked these similar questions
Researchers know that Fru-M controls male sexualbehavior in Drosophila because inappropriate Fru-Mexpression in females causes them to behave likemales: Such females display male behaviors that areoriented toward other females.a. Describe a fru mutation that could cause the expression of Fru-M in females.b. Describe a transgene construct that scientistscould generate and insert into Drosophila femalesthat would have the same effect as the mutant youdescribed in (a).
A researcher has identified a mutant strain of yeast whose histones are unable to be acetylated. Which of the following is the MOST reasonable prediction for how the phenotype of this mutant yeast will differ from the phenotype of yeast cells with acetylated histones?
A. The mutant will grow more rapidly.
B. The mutant will grow much more slowly.
C. The mutant will show decreased levels of gene expression.
D. The mutant will show increased levels of gene expression.
Imagine a scenario in which prenatal testing of a human female fetus indicates that the baby will have a normal XX karyotype but is heterozygous for a mutation that inactivates the Xist promoter. Allele “Xr” represents the mutated version of the Xist promoter, and “XR” represents the normal version of the Xist promoter.
How will this mutation affect the process of X inactivation?A. "X inactivation will still be random with both mutant and normal X chromosomes being randomly inactivated"
B. "The chromosome with the mutant Xist promoter will always be active"
C. "The chromosome with the mutant Xist promoter will always be inactivated"
D. "The normal X chromosome (no mutation in Xist) will always be active"
E. "The normal X chromosome (no mutation in Xist) will always be inactivated"
Chapter 17 Solutions
ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
Ch. 17 - For each of the terms in the left column, choose...Ch. 17 - For each of the following types of gene...Ch. 17 - List five events other than transcription...Ch. 17 - Which eukaryotic RNA polymerase RNA pol I, pol II,...Ch. 17 - As shown in the following diagram, a single...Ch. 17 - You have synthesized an enhancerless GFP reporter...Ch. 17 - Prob. 7PCh. 17 - Prob. 8PCh. 17 - A single UAS regulates the expression of three...Ch. 17 - MyoD is a transcriptional activator that turns on...
Ch. 17 - a. Assume that two transcription factors are...Ch. 17 - Prob. 12PCh. 17 - In Problem 12, you identified a genomic region...Ch. 17 - Prob. 14PCh. 17 - Prob. 15PCh. 17 - Genes in both prokaryotes and eukaryotes are...Ch. 17 - Prob. 17PCh. 17 - Lysine 4 of histone H3 H3K4 is methylated in the...Ch. 17 - J.T. Lis and collaborators have developed an...Ch. 17 - Hydatiform moles are growths of undifferentiated...Ch. 17 - Prader-Willi syndrome is caused by a mutation in...Ch. 17 - The human IGF2 gene is autosomal and maternally...Ch. 17 - Follow the expression of a paternally imprinted...Ch. 17 - Reciprocal crosses were performed using two inbred...Ch. 17 - Interestingly, imprinting can be tissue-specific....Ch. 17 - Prob. 26PCh. 17 - A method for detecting methylated CpGs involves...Ch. 17 - Honeybees Apis mellifera provide a striking...Ch. 17 - Consider the experiment in Fig. 17.24, where the...Ch. 17 - A protein or RNA that regulates gene expression in...Ch. 17 - a. How can a single eukaryotic gene give rise to...Ch. 17 - A hunchback gene, a gene necessary for proper...Ch. 17 - You know that the mRNA and protein produced by a...Ch. 17 - You are studying a transgenic mouse strain that...Ch. 17 - Prob. 35PCh. 17 - Scientists have exploited the siRNA pathway to...Ch. 17 - Persimmons Diospyros lotus are dioecious plants,...Ch. 17 - Drosophila females homozygous for loss-of-function...Ch. 17 - The text has discussed the RNA-Seq technique,...Ch. 17 - Researchers know that Fru-M controls male sexual...Ch. 17 - The Drosophila gene Sex lethal Sxl is deserving of...Ch. 17 - Figure 17.29 shows that the Sxl protein binds to...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- You are interested in finding out in which organ GTF2H5 is highly expressed experimentally. Describe a method in recombinant DNA technology to measure gene expression, explain your rationale, and step by step, what are needed for this method to workarrow_forwarda. The eyeless gene is required for eye formation in Drosophila. It encodes a homeodomain. What would you predict about the biochemical function of the Eyeless protein?b. Where would you predict that the eyeless gene is expressed in development? How would you test your prediction? c. The Small eye and Aniridia genes of mice and humans, respectively, encode proteins with very strong sequence similarity to the fly Eyeless protein, and they are named for their effects on eye development. Devise one test to examine whether the mouse and human genes are functionally equivalent to the fly eyeless gene.arrow_forwardA. Deletion of the SOX9 gene leads to sex reversal resulting in a person with karyotype 46XY being phenotypically Explain the genetic basis for this. B. Describe what would happen to the phenotype of a male with a mutation in the gene encoding SF1? Explain your answer.arrow_forward
- Which of the following does NOT pertain to the myoblast-determining gene 1?*a. It is a master gene.b. It is a silencing gene.c. It produces a transactivating protein.d. It activates its own gene. Gene silencing involves which type of histone modification?* a. acetylation of histone 4 b. dimethylation of histone 3 c. trimethylation of histone 4 d. trimethylation of histone 3 Given the required environment, the totipotency of the nucleus can allow which of the following?* a. a committed cell to undergo dedifferentiation b. a committed cell to undergo terminal differentiation c. a terminally differentiated cell to produce a complete organism d. a terminally differentiated cell to produce specific types of tissues An induced pluripotent cell is described by which of the following?* a. It is a committed cell that undergoes redifferentiation. b. It is a committed cell that undergoes dedifferentiation. c. It is a terminally…arrow_forwardSuppose a researcher has three different Drosophila strains that have mutations in the bicoid gene called bicoid-A, bicoid-B, and bicoid-C; the wild type is designated bicoid +. To study these mutations, phenotypically normal female flies that are homozygous for the given bicoid mutation were obtained, and their oocytes were analyzed using a Northern blot to determine the size and/or amount of the bicoid mRNA and in situ hybridization to determine the bicoid mRNA location within the oocyte. A wild-type strain was also analyzed as a control. In both cases, the probe was complementary to the bicoid mRNA and the results are shown below. (Anterior is on the left; posterior is on the right.) Northern blot 1 2 - 3 4 In situ hybridization Wild type Lane 1. Wild type (bicoid*) Lane 2. bicoid-A Lane 3. bicoid-B Lane 4. bicoid-C bicoid-B bicoid-A bicoid-C Which mutation is likely to cause the embryo to develop two "anterior" ends? bicoid-B Obicoid-A bicoid-Carrow_forwardMyoD is a transcriptional activator that turns on theexpression of several muscle-specific genes in humancells. The Id gene product inhibits MyoD action.a. One possibility is that the Id protein directly represses the expression of these muscle-specificgenes. Explain how Id would function if it were arepressor.b. Another possibility is that Id inhibits musclespecific gene transcription indirectly, by preventingMyoD function. Explain how Id could function asan indirect repressor.c. Suppose you know the amino acid sequence ofthe Id protein. How might this information supportthe hypothesis in part (a) or in part (b)?arrow_forward
- a) hours: 0 2 567 DMC1 SPS1 hours: 0 2 5 6 7 9 11 DIT1 SPS100 Oxygen level (% normal) b) 120 100 FIGURE 4.6. Comparison of Northern blots with DNA microarray data. a) Results from four individual Northern blots examining four different genes and measuring mRNA production over time, as indicated. b) Results from a series of microarrays for the same four genes of interest. Note the color scale on the bottom of b), where bright green indicates a 20-fold repression and bright red indicates a 20-fold induction. Black indicates no change in transcription (i.e., the merged microarray spot would have appeared yellow). 80 60 40 20 0 1 2 gene X gene Y gene Z 3 1 hour 1.0 1.0 b) 1.0 hours: 0.5 2 5 7 9 11 DMC1 SPS1 DIT1 SPS100 fold repressed >20 10x 3x3x10x >20 1:1 fold induced 4 5 6 7 8 9 10 11 Time (hours) 3 hour 2.2 4.5 1.5 5 9 hour hour 1.0 0.15 0.95 0.05 2.0 2.0 FIGURE 4.7 Transcriptional response of three genes to the gradual loss of oxygen. a) Graph of oxygen con- sumption over time by…arrow_forwardProlactin is a protein hormone that, among other things, enables mammals to produced milk. Prolactin is secreted from cells in the pituitary gland in response to eating, mating, ovulation, and nursing. a. Prolactin is encoded by the PRL A segment of the PRL gene and its regulatory regions are shown below. The +1 site (*) and part of the promoter (#) of PRL are indicated. What is the PRL mRNA transcribed from the PRL gene? 5'-AAGCCGACCGGATATACGACGCCATGAACATGACAGGATCGCCATGG-3' 3'-TTCGGCTGGCCTATATGCTGCGGTACTTGTACTGTCCTAGCGGTACC-5' #### * b. What is the 5'-UTR of PRL? c. Using the mRNA you transcribed in part a, what are the first 8 amino acids of prolactin that are translated? cis face trans face MTOC Rough ER Golgi complex Cell membrane c. In what organelle is prolactin glycosylated? What motor protein would be used to transport prolactin from the rough ER to this organelle? d. Where does exocytosis occur? What motor protein would be used to transport prolactin from the site of its…arrow_forwardAn epigenetic study of maternal care in mice was used to study transgenerational epigenetic inheritance. This study found that A. Increased maternal care during childhood resulted in lower stress levels as adults and decreased maternal care with their own offspring B. Increased maternal care during childhood resulted in lower stress levels as adults and increased maternal care with their own offspring. C. Increased maternal care during childhood resulted in higher stress levels as adults and decreased maternal care with their own offspring. D. Increased maternal care during childhood resulted in higher stress levels as adults and increased maternal care with their own offspring.arrow_forward
- Expression of recombinant proteins in yeast is an important tool for biotechnology companies that produce new drugs for human use. In an attempt to get a new gene X expressed in yeast, a researcher has integrated gene X into the yeast genome near a telomere. Will this strategy result in good expression of gene X? Why or why not? Would the outcome of this experiment differ if the experiment had been performed in a yeast line containing mutations in the H3 or H4 histone tails?arrow_forwardFor the Igf2 gene, where do de novo methylation and maintenancemethylation occur?a. De novo methylation occurs in sperm, and maintenancemethylation occurs in egg cells.b. De novo methylation occurs in egg cells, and maintenancemethylation occurs in sperm cells.c. De novo methylation occurs in sperm, and maintenancemethylation occurs in somatic cells of offspring.d. De novo methylation occurs in egg cells, and maintenancemethylation occurs in somatic cells of offspring.arrow_forwardOur understanding of maternal effect genes has been greatly aided by their identification in experimental organisms such as Drosophila melanogaster and Caenorhabditis elegans. In experimental organisms with a short generation time, geneticists have successfully searched for mutant alleles that prevent the normal process of embryonic development. In many cases, the offspring die at early embryonic or larval stages. These are called maternal effect lethal alleles. How would a researcher identify a mutation that produced a recessive maternal effect lethal allele?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSONBiology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStaxAnatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
- Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & CompanyLaboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education
![Text book image](https://www.bartleby.com/isbn_cover_images/9780134580999/9780134580999_smallCoverImage.gif)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
![Text book image](https://www.bartleby.com/isbn_cover_images/9781947172517/9781947172517_coverImage_Textbooks.gif)
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
![Text book image](https://www.bartleby.com/isbn_cover_images/9781259398629/9781259398629_smallCoverImage.gif)
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
![Text book image](https://www.bartleby.com/isbn_cover_images/9780815344322/9780815344322_smallCoverImage.gif)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
![Text book image](https://www.bartleby.com/isbn_cover_images/9781260159363/9781260159363_smallCoverImage.gif)
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
![Text book image](https://www.bartleby.com/isbn_cover_images/9781260231700/9781260231700_smallCoverImage.gif)
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
Embryology | Fertilization, Cleavage, Blastulation; Author: Ninja Nerd;https://www.youtube.com/watch?v=8-KF0rnhKTU;License: Standard YouTube License, CC-BY