Concept explainers
(a)
Interpretation:
Possible mechanism for the given reaction has to be proposed.
Concept Introduction:
Reaction of an ester with ammonia or an
Treatment of an ester with ammonia or a primary or secondary amine gives an amide.
The nucleophilic addition of the ammonia or amine to the carbonyl carbon occurs followed by a proton transfer and a tetrahedral addition intermediate is formed. The intermediate can directly alkoxide and lose a proton to the alkoxide to give products.
(b)
Interpretation:
More acidic has to be identified in the given barbital molecule and the acidity of this molecule has to be accounted.
Concept Introduction:
Where,
If we know which proton is the more acidic and which proton is the less acidic we can make the determination regarding basicity.
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Chapter 18 Solutions
Organic Chemistry
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