Chapter 18, Problem 18.53P

Interpretation Introduction

Interpretation:

A synthesis has to be proposed for cyclomethycaine from 4-hydroxybenzoic acid and 2-methylpiperidine.

Concept introduction:

Esterification reaction:

In an esterification reaction, carboxylic acid combines with an alcohol in presence of little concentrated sulphuric acid to produce an ester.

Esters reacts with ammonia to form amides.

Acid chlorides are most often prepared by treating a carboxylic acid with thionyl chloride.

$LiAl{H}_4$ is a powerful reducing agent which reduces carboxylic acids to primary alcohol.