a. To determine: The type of cyclins (A, B, D, or E) to which SCF and APC couple ubiquitin. Introduction: The duplication of chromosomes and their accurate segregation into two daughter cells takes place during the cell cycle. The cell cycle is divided into four successive stages: G 1 , S, G 2 , and M. The cyclin-dependent kinases belong to a family of protein kinases that regulate the transition of the cell cycle from one stage to the next stage.

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Answer 1

Question

Chapter 19, Problem 11P

Summary Introduction

a.

To determine:

The type of cyclins (A, B, D, or E) to which SCF and APC couple ubiquitin.

Introduction:

The duplication of chromosomes and their accurate segregation into two daughter cells takes place during the cell cycle. The cell cycle is divided into four successive stages: G₁, S, G₂, and M. The cyclin-dependent kinases belong to a family of protein kinases that regulate the transition of the cell cycle from one stage to the next stage.

Summary Introduction

b.

To determine:

The method by which cells might activate SCF and APC only at the correct times.

Introduction:

The cyclin-dependent kinases function only after associating with proteins called cyclins. CDK-cyclin complexes can activate or deactivate target proteins by phosphorylation.

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Students have asked these similar questions

The destruction of the various cyclins is commonly used to inactivate the Cdk/cyclin complexes. Why is it advantageous to inactivate these complexes via protein destruction instead of some other method that does not require the re-synthesis of a cyclin protein the next time the cell divides?

Rather surprisingly, some cellular components that we know best from our study of nuclear protein traffic also appear to be involved in the process of spindle assembly. These include Ran GEF (which, as you may recall, is bound to chromatin – an association that apparently continues even when the nuclear envelope breaks down at the onset of mitosis) and importin-β. Now think back to the process of nuclear protein import. To which form of Ran (Ran-GDP or Ran-GTP) does importin-β bind and what is the significance of that interaction with respect to the efficiency of delivery of import “cargo” to the nucleus? To which form of Ran (Ran-GDP or Ran-GTP) do exportins bind and what is the significance of that interaction with respect to the efficiency of delivery of export “cargo” to the cytoplasm?

After a cell "clears" the G₁ restriction checkpoint, it can proceed into S phase. This S phase entry is achieved by a cyclin dependent kinase (Cdk2) and its cyclin (Cyclin E), but additionally requires the action of a protein kinase (CDC2) as well as a phosphatase (CDC25) enzyme. Explain how these 4 proteins work together to orchestrate S phase entry.

Answer 2

Question

Chapter 19, Problem 11P

Summary Introduction

a.

To determine:

The type of cyclins (A, B, D, or E) to which SCF and APC couple ubiquitin.

Introduction:

The duplication of chromosomes and their accurate segregation into two daughter cells takes place during the cell cycle. The cell cycle is divided into four successive stages: G₁, S, G₂, and M. The cyclin-dependent kinases belong to a family of protein kinases that regulate the transition of the cell cycle from one stage to the next stage.

Summary Introduction

b.

To determine:

The method by which cells might activate SCF and APC only at the correct times.

Introduction:

The cyclin-dependent kinases function only after associating with proteins called cyclins. CDK-cyclin complexes can activate or deactivate target proteins by phosphorylation.

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 3

Question

Chapter 19, Problem 11P

Summary Introduction

a.

To determine:

The type of cyclins (A, B, D, or E) to which SCF and APC couple ubiquitin.

Introduction:

The duplication of chromosomes and their accurate segregation into two daughter cells takes place during the cell cycle. The cell cycle is divided into four successive stages: G₁, S, G₂, and M. The cyclin-dependent kinases belong to a family of protein kinases that regulate the transition of the cell cycle from one stage to the next stage.

Summary Introduction

b.

To determine:

The method by which cells might activate SCF and APC only at the correct times.

Introduction:

The cyclin-dependent kinases function only after associating with proteins called cyclins. CDK-cyclin complexes can activate or deactivate target proteins by phosphorylation.

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 4

Question

Chapter 19, Problem 11P

Summary Introduction

a.

To determine:

The type of cyclins (A, B, D, or E) to which SCF and APC couple ubiquitin.

Introduction:

The duplication of chromosomes and their accurate segregation into two daughter cells takes place during the cell cycle. The cell cycle is divided into four successive stages: G₁, S, G₂, and M. The cyclin-dependent kinases belong to a family of protein kinases that regulate the transition of the cell cycle from one stage to the next stage.

Summary Introduction

b.

To determine:

The method by which cells might activate SCF and APC only at the correct times.

Introduction:

The cyclin-dependent kinases function only after associating with proteins called cyclins. CDK-cyclin complexes can activate or deactivate target proteins by phosphorylation.

Expert Solution & Answer

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Answer 5

Chapter 19, Problem 11P

Summary Introduction

a.

To determine:

The type of cyclins (A, B, D, or E) to which SCF and APC couple ubiquitin.

Introduction:

The duplication of chromosomes and their accurate segregation into two daughter cells takes place during the cell cycle. The cell cycle is divided into four successive stages: G₁, S, G₂, and M. The cyclin-dependent kinases belong to a family of protein kinases that regulate the transition of the cell cycle from one stage to the next stage.

Summary Introduction

b.

To determine:

The method by which cells might activate SCF and APC only at the correct times.

Introduction:

The cyclin-dependent kinases function only after associating with proteins called cyclins. CDK-cyclin complexes can activate or deactivate target proteins by phosphorylation.

Answer 6

Chapter 19, Problem 11P

Summary Introduction

a.

To determine:

The type of cyclins (A, B, D, or E) to which SCF and APC couple ubiquitin.

Introduction:

The duplication of chromosomes and their accurate segregation into two daughter cells takes place during the cell cycle. The cell cycle is divided into four successive stages: G₁, S, G₂, and M. The cyclin-dependent kinases belong to a family of protein kinases that regulate the transition of the cell cycle from one stage to the next stage.

Answer 7

Chapter 19, Problem 11P

Summary Introduction

a.

To determine:

The type of cyclins (A, B, D, or E) to which SCF and APC couple ubiquitin.

Introduction:

The duplication of chromosomes and their accurate segregation into two daughter cells takes place during the cell cycle. The cell cycle is divided into four successive stages: G₁, S, G₂, and M. The cyclin-dependent kinases belong to a family of protein kinases that regulate the transition of the cell cycle from one stage to the next stage.

Answer 8

Summary Introduction

b.

To determine:

The method by which cells might activate SCF and APC only at the correct times.

Introduction:

The cyclin-dependent kinases function only after associating with proteins called cyclins. CDK-cyclin complexes can activate or deactivate target proteins by phosphorylation.

Answer 9

Summary Introduction

b.

To determine:

The method by which cells might activate SCF and APC only at the correct times.

Introduction:

The cyclin-dependent kinases function only after associating with proteins called cyclins. CDK-cyclin complexes can activate or deactivate target proteins by phosphorylation.

Answer 10

Expert Solution & Answer

Answer 11

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Answer 12

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Answer 13

Ch. 19 - For each of the terms in the left column, choose...Ch. 19 - Characterize the differences between tumor cells...Ch. 19 - Prob. 3P Ch. 19 - Prob. 4P Ch. 19 - A carcinogenic compound is placed on the skin of...Ch. 19 - Prob. 6P Ch. 19 - Prob. 7P Ch. 19 - Molecules outside and inside the cell regulate the...Ch. 19 - Put the following steps in the correct ordered...Ch. 19 - a. Would you expect a cell to continue or to stop...

Solution Summary: The author explains how cyclin-dependent kinases regulate the transition of the cell cycle from one stage to the next.

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b.

To determine:

The method by which cells might activate SCF and APC only at the correct times.

Introduction:

The cyclin-dependent kinases function only after associating with proteins called cyclins. CDK-cyclin complexes can activate or deactivate target proteins by phosphorylation.

Want to see the full answer?

Chapter 19 Solutions

Solution Summary: The author explains how cyclin-dependent kinases regulate the transition of the cell cycle from one stage to the next.

Concept explainers

Videos

b. To determine: The method by which cells might activate SCF and APC only at the correct times. Introduction: The cyclin-dependent kinases function only after associating with proteins called cyclins. CDK-cyclin complexes can activate or deactivate target proteins by phosphorylation.

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Chapter 19 Solutions

b.

To determine:

The method by which cells might activate SCF and APC only at the correct times.

Introduction:

The cyclin-dependent kinases function only after associating with proteins called cyclins. CDK-cyclin complexes can activate or deactivate target proteins by phosphorylation.