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Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 19, Problem 16P
A female patient 19 years old, whose symptoms are anemia and internal bleeding due to a massive buildup of leukemic white blood cells, is diagnosed with chronic myelogenous leukemia (CML). Karyotype analysis shows that the leukemic cells of this patient are heterozygous for a reciprocal translocation involving chromosomes 9 and 22. However, none of the normal, nonleukemic cells of this patient contain the translocation. Which of the following statements is true and which is false?
a. | The translocation results in the inactivation (loss of function) of a tumor-suppressor gene. |
b. | The translocation results in the inactivation (loss of function) of an oncogene. |
c. | There is a 50% chance that any child of this patient will have CML. |
d. | This patient is a somatic mosaic in terms of the karyotype. |
e. | DNA extracted from leukemic cells of this patient, if taken up by normal mouse tissue culture cells, could potentially transform the mouse cells into cells capable of causing tumors. |
f. | The normal function of the affected tumor-suppressor gene or proto-oncogene at the translocation breakpoint could potentially block the function of the cyclin proteins that drive the cell cycle forward. |
g. | Two rare events must have occurred to disrupt both copies of the tumor-suppressor gene or proto-oncogene at the translocation breakpoint in the leukemic cells. |
h. | A possible treatment of leukemia would involve a drug that would turn on the expression of the tumorsuppressor gene or oncogene at the translocation breakpoint in the leukemic cells. |
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Chapter 19 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 19 - For each of the terms in the left column, choose...Ch. 19 - Characterize the differences between tumor cells...Ch. 19 - Prob. 3PCh. 19 - Prob. 4PCh. 19 - A carcinogenic compound is placed on the skin of...Ch. 19 - Prob. 6PCh. 19 - Prob. 7PCh. 19 - Molecules outside and inside the cell regulate the...Ch. 19 - Put the following steps in the correct ordered...Ch. 19 - a. Would you expect a cell to continue or to stop...
Ch. 19 - Prob. 11PCh. 19 - One of the hallmarks of mitotic anaphase is the...Ch. 19 - Concerning the Tools of Genetics Box Analysis of...Ch. 19 - Are genome and karyotype instabilities...Ch. 19 - Prob. 15PCh. 19 - A female patient 19 years old, whose symptoms are...Ch. 19 - Prob. 17PCh. 19 - Prob. 18PCh. 19 - Neurofibromatosis type 1 NF1; also known as von...Ch. 19 - Hepatocellular carcinoma is the most frequent form...Ch. 19 - Prob. 21PCh. 19 - Prob. 22PCh. 19 - Prob. 23P
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