![Genetics: From Genes to Genomes, 5th edition](https://www.bartleby.com/isbn_cover_images/9780073525310/9780073525310_largeCoverImage.gif)
Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
expand_more
expand_more
format_list_bulleted
Concept explainers
Textbook Question
Chapter 19, Problem 9P
Put the following steps in the correct ordered sequence.
a. | kinase cascade |
b. | activation of a transcription factor |
c. | hormone binds transmembrane receptor |
d. | expression of target genes in the nucleus |
e. | Ras molecular switch |
Expert Solution & Answer
![Check Mark](/static/check-mark.png)
Want to see the full answer?
Check out a sample textbook solution![Blurred answer](/static/blurred-answer.jpg)
Students have asked these similar questions
Binding of a ligand (like TGFA) to a receptor tyrosine kinase (RTK) causes all of the following except (can use cell):
OA. Dimerization of the receptor
B. Auto-phosphorylation of the receptor
O C. Activation of Ras through an interction with GRB2 (an adaptor) and SOS (a GEF) proteins.
O D. Activation of heterotrimeric G proteins
Which of the following defects in RAS would be tumorigenic? multiple answers
A.
Deletion of nucleotide binding domain
B.
Inactivation of Guanine Exchange Factor (GEF)
C.
Mutation at amino acid 61 that prevents hydrolysis of bound GTP
D.
Inactivation of GTPase Protein (GAPS)
E.
Mutation that prevents binding of GTP
Which of the following statements are correct about cytoplasmic signaling in cancer cells? Multiple answers.
A.
Only minor modifications of cell control machinery are required for normal cells to become highly proliferating cancer cells
B.
Immediate early genes are induced in the presence of protein synthesis inhibitors
C.
Many immediate -early genes are oncogenes
D.
Delayed early genes are highly expressed in the presence of protein synthesis inhibitors
E.
Delayed early genes are highly expressed in normal cells in the absence of growth factors
Chapter 19 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 19 - For each of the terms in the left column, choose...Ch. 19 - Characterize the differences between tumor cells...Ch. 19 - Prob. 3PCh. 19 - Prob. 4PCh. 19 - A carcinogenic compound is placed on the skin of...Ch. 19 - Prob. 6PCh. 19 - Prob. 7PCh. 19 - Molecules outside and inside the cell regulate the...Ch. 19 - Put the following steps in the correct ordered...Ch. 19 - a. Would you expect a cell to continue or to stop...
Ch. 19 - Prob. 11PCh. 19 - One of the hallmarks of mitotic anaphase is the...Ch. 19 - Concerning the Tools of Genetics Box Analysis of...Ch. 19 - Are genome and karyotype instabilities...Ch. 19 - Prob. 15PCh. 19 - A female patient 19 years old, whose symptoms are...Ch. 19 - Prob. 17PCh. 19 - Prob. 18PCh. 19 - Neurofibromatosis type 1 NF1; also known as von...Ch. 19 - Hepatocellular carcinoma is the most frequent form...Ch. 19 - Prob. 21PCh. 19 - Prob. 22PCh. 19 - Prob. 23P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- State whether the level of each of the following protein in a cancer cell is higher or lower than normal and how is that beneficial to the cancer cell? a. ARF protein b. MDM2 c. caspases d. Fas receptor e. TNF-α (new answer & typed please)arrow_forwardWe have studied Ras signal transduction pathway. In an experiment, two different mutations were produced using different chemicals. The proteins with mutation are listed below. State what will be the effect of each mutation and explain whether it will result in cell proliferation or not. GEF protein GTPasearrow_forwardIf a cell expresses a dominant-negative tyrosine-kinase-linked receptor (RTK) that lacks the kinase domain, which of the following will still happen in response to a growth factor that binds the RTK? A Receptor cross-phosphorylation. Activation of target proteins by Ras. C) Receptor dimerization. D) Binding of the growth factor to its receptor. Interaction of Ras with the activated receptor. Barrow_forward
- Which of the following are characteristics of “small” monomeric Ras GTPases? A. Membrane bound B. Act as molecular switches between GTP & GDP C. They interact with receptors directly to regulate upstream events D. They are activated upon GTP binding E. None of the abovearrow_forwardState whether the level of each of the following protein in a cancer cell is higher or lower than normal and how is that beneficial to the cancer cell? a. ARF protein b. MDM2 c. caspases d. Fas receptor e. TNF-αarrow_forwardWhich of the following consequences of mutations would likely to be associated with an increased cancer risk? (select all that apply)? A. Truncation of the EGF receptor B. Constitutive activation of K-Ras C. Amplification of myc D. Truncation of H-Ras due to a premature stop codon E. Amplification of ErbB2arrow_forward
- Which of the following statements regarding signaling in normal cells and cancer cells is false? a. In normal cells, RTK transphosphorylation is strictly dependent on ligand binding. Ligand binding promotes a conformational change in the RTKS that is required for dimerization, and dimerization is required for transphosphorylation. b. Cancers cells that over-express RTK's can respond to tiny amounts of ligand, and in some instances signaling can be ligand-independent. c. Cancer cells that have established several autocrine signaling loops have a poor prognosis, because these cells have enabled multiple independent mitogenic signal transduction pathways. 4 d. The extracellular ectodomains of all RTKS are highly conserved in primary sequence and structure. e. RTKS have a hydrophilic extracellular ectodomain, and hydrophobic transmembrane domain, and a hydrophilic cytoplasmic domain, which contains the catalytic portion of the protein.arrow_forwardPut the following steps in the correct orderedsequence.a. kinase cascadeb. activation of a transcription factorc. hormone binds transmembrane receptord. expression of target genes in the nucleuse. Ras molecular switcharrow_forward5) Briefly explain why the formation of a tumour can pose a risk to a person's homeostasis. 6) The functioning of the "Ras/MAPK" signal transduction pathway is absolutely essential in order for cells to grow, divide, and migrate. One important protein that is part of this pathway is BRAF. This protein is a kind of enzyme called a "kinase" – an enzyme that transfers a phosphate group onto another protein. In some melanomas, a mutated form of BRAF called BRAF Val600AGlu drives the progression of the cancer. The drug "vemurafenib" slows the progression of the cancer by slowing the production of the mutant BRAF protein. (National Cancer Institute. 2019. Types of Cancer Treatment. Retrieved from: https://www.cancer.gov/about-cancer/treatment/types/ Is this an example of a traditional cancer therapy or a targeted therapy? Briefly explain your reasoning in the space provided, using information provided in the text to support your answer. Type of therapy (traditional or targeted)?: Brief…arrow_forward
- Which of the following modifications of the Epithelial Growth Factor Receptor (EGFR) would be proliferative of epithelial cells? multiple answers A. Mutation of active site residue responsible for tyrosine phosphorylation. B. Deletion of extracellular ectodomain C. Mutation in ectodomain that prevents binding of EGF D. Cell expresses EGF E. Mutation in promoter that increases expression of EGF receptor F. Dimerization of receptor without growth factor G. Mutation in EGFR promoter that decreases expression of receptorarrow_forwardA particular drug inhibits the protein kinase that is responsible for phosphorylating the CREB protein. How would this drug affect the following events? A. The ability of the CREB protein to bind to CREs B. The ability of extracellular hormones to enhance cAMP levels C. The ability of the CREB protein to stimulate transcription D. The ability of the CREB protein to dimerizearrow_forwardG protein coupled receptors play an important role in signal transduction in many cells. Label the four essential components of the G protein coupled receptor signaling system (blanks a-d in the picture) by choosing from the menus below. a b b Each answer will be used at most once, while some will not be used at all (select one for each): Group of answer choices transcription factor с transcription factor Show Transcribed Text d transcription factor B C. transcription factor G protein second messenger G protein second messenger IE G protein second messenger G protein second messenger receptor receptor receptor receptor enzyme enzyme enzyme enzyme steroid hormone steroid hormone steroid hormone steroid hormonearrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Biology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
![Text book image](https://www.bartleby.com/isbn_cover_images/9781947172517/9781947172517_coverImage_Textbooks.gif)
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Immune System and Immune Response Animation; Author: Medical Sciences Animations;https://www.youtube.com/watch?v=JDdbUBXPKc4;License: Standard YouTube License, CC-BY
Immune response: summary; Author: Dr Bhavsar Biology;https://www.youtube.com/watch?v=ADANgHkX4OY;License: Standard Youtube License