Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 19, Problem 4P
Summary Introduction
To determine:
Whether the views regarding germ-line mutations and environmental factors as the cause of cancer conflicting or can be reconciled.
Introduction:
Any abnormal change in the gene sequence is known as mutation. Mutations can lead to various ailments, including cancer. Mutations can lead to uncontrollable growth of the cells leading to the development of cancer.
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Chapter 19 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 19 - For each of the terms in the left column, choose...Ch. 19 - Characterize the differences between tumor cells...Ch. 19 - Prob. 3PCh. 19 - Prob. 4PCh. 19 - A carcinogenic compound is placed on the skin of...Ch. 19 - Prob. 6PCh. 19 - Prob. 7PCh. 19 - Molecules outside and inside the cell regulate the...Ch. 19 - Put the following steps in the correct ordered...Ch. 19 - a. Would you expect a cell to continue or to stop...
Ch. 19 - Prob. 11PCh. 19 - One of the hallmarks of mitotic anaphase is the...Ch. 19 - Concerning the Tools of Genetics Box Analysis of...Ch. 19 - Are genome and karyotype instabilities...Ch. 19 - Prob. 15PCh. 19 - A female patient 19 years old, whose symptoms are...Ch. 19 - Prob. 17PCh. 19 - Prob. 18PCh. 19 - Neurofibromatosis type 1 NF1; also known as von...Ch. 19 - Hepatocellular carcinoma is the most frequent form...Ch. 19 - Prob. 21PCh. 19 - Prob. 22PCh. 19 - Prob. 23P
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Which of the following mutations will result in cancer? a. homozygous recessive mutation in a tumor-suppressor gene coding for a nonfunctional protein b. dominant mutation in a tumor-suppressor gene in which the normal protein product is overexpressed c. homozygous recessive mutation in which there is a deletion in the coding region of a proto-oncogene, leaving it nonfunctional d. dominant mutation in a proto-oncogene in which the normal protein product is overexpressedarrow_forwardDespite all that we know about cancer today, some types of cancers are still increasing in frequency. Lung cancer among nonsmoking women is one of these. What reason(s) might there be for this increasing problem?arrow_forwardThere are three broad categories of cancer-related genes: proto-oncogenes, tumor suppressor genes, and DNA stability/repair genes. Define each of these categories and indicate which one you think the RB1 gene belongs to and why.arrow_forward
- What is meant by the "two-hit" model of cancer development? Describe this theory in detail and explain why this makes sense with the observation that cancer is typically seen in people who are >60 years of age.arrow_forwardWhat are the heritable changes in cells that contribute to cancer development?arrow_forwardDistinguish between proto-oncogenes and tumor-suppressor genes. To become cancer promoting, do proto-oncogenes and tumor-suppressor genes undergo gain-of-function or loss-of-function mutations? Classify the following genes as proto-oncogenes or tumor-suppressor genes: p53, ras, BCL-2, JUN, MDM2, and p16.arrow_forward
- Although cancer is not a contagious disease in humans or other vertebrates, there have been rare cases in which cancers have spread from one organism to another. Describe three cases of these contagious cancers and what conditions might have led to their appearance. For an introduction to this topic, see http:// www.cancer.org/cancer/cancerbasics/is-cancer-contagious.arrow_forwardWhat separates cancer cells from normal cells? Describe one form of mutation that can increase the risk of a normal cell being cancerous.arrow_forwardPlease discuss the difference between cancers caused by tumor viruses and cancers caused by oncogenes. Does the etiology of a cancer influence its manifestation?arrow_forward
- With regard to cancer cells, which of the following are true? A. Cancer cells are clonal, meaning that they are derived from many different cells that all underwent the same clonal mutation. Cells usually accumulate many mutations over time, and this results in cancerous growth. B. Almost all cancers are caused by oncogenic viruses. no Benign tumors are dangerous because they can easily invade surrounding tissue and spread to other locations in the body. DE. Cancer cells are unable to control their division.arrow_forwardWhat is cancer? What defects are commonly found in cancer cells? Do all cancer cells have mutations in the same genes? Explain.arrow_forwardWhat are Ras protein and p53? How can mutations in the genes for these proteins contribute to cancer?arrow_forward
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