Concept explainers
(a)
Interpretation:
An explanation corresponding to the given statement that guanidine is a stronger base than other
Concept introduction:
Basicity of amines depends upon the nature of substituent present on the
(b)
Interpretation:
An explanation corresponding to the given statement that p-nitroaniline is a weaker base than aniline is to be stated.
Concept introduction:
Basicity of amines depends upon the nature of substituent present on the aromatic ring. If substituent is electron withdrawing group then it has tendency to decrease the electron density and thus result in decrease in basicity of amines, whereas electron donating groups enhance the electron density and increase the basicity.
(c)
Interpretation:
An explanation corresponding to the given statement that
Concept introduction:
Basicity of amines depends upon the nature of substituent present on the aromatic ring. If substituent is electron withdrawing group then it has tendency to decrease the electron density and thus result in decrease in basicity of amines, whereas electron donating groups enhance the electron density and increase the basicity.
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ORGANIC CHEMISTRY MASTERINGCHEM ACCESS
- Which Amine is the weakest base? Explain why. A.) NH3 B.) NH2CH3 C.) NH2F D.) NHCH2CH3 E.) NH2Brarrow_forwardDetermine which producevthe least basic primary amine 1. NaN3 2.H2/Pd Br А. H2/Pd,C 'NO2 Br 1. NaCN/HCI 2.H2/Pd,C С. D. A and C B.arrow_forwardWhich are viable ways to prepare the amine shown? || H NH + N ZI N NaBH3CN NaBH3CN A. Method I only B. Method II only C. Both methods are viable. D. Neither method is viable.arrow_forward
- Triethylenemelamine (TEM) is an antitumor agent. Its activity is due to its ability to cross-link DNA. a. Explain why it can be used only under slightly acidic conditions. b. Explain why it can cross-link DNA.arrow_forwardHelp me pleasearrow_forwardSynthadotin is a promising anticancer drug in clinical trials. a.Identify the functional groups. b.Classify any amine or amide as 1°, 2°, or 3°. c.At which sites can synthadotin hydrogen bond to another molecule like itself? d. Label two nucleophilic sites. e. Label two electrophilic sites. f. What product is formed when synthadotin is treated with HCl?arrow_forward
- 22. The stability of carbocation can be accounted by which of the following structural effect? a. hyperconjugation b. inductive effect d. both a andb C. resonance 23. Secondary amines are more basic than primary amines because of what structural effect? a. hyperconjugation b. inductive effect C. resonance d. steric effectarrow_forwardAnswer each question about oxycodone, a narcotic analgesic used for severe paina.Identify the functional groups in oxycodone. b.Classify any alcohol, amide, or amine as 1°, 2°, or 3°. c.Which proton is most acidic? d. Which site is most basic? e.What is the hybridization of the N atom? f. How many sp2 hybridized C atoms does oxycodone contain?arrow_forward1. Biogenic Amines are inactivated primarily by a. Sulfonation b. Glucoronidation c. Aromatic hydroxylation d. Methylation 2. A drug can exert its pharmacological effect only if it is a. Protein bound b. Protein unbound c. Free drug d. Both B & C e. Both A & C 3. In order for the drug to be ready and available for absorption, it must be release first from its dosage form with the exception of: a. Capsule b. Tablet c. Solution d. Suspension 4. All of the following are true, except a. Solubility increase with decrease particle size b. Solubility increase with increase surface area c. Solubility increase with increase particle size d. Solubility decrease with decrease surface area 5. The rate in which the drug appears in the bloodstream is also known as a. Half-life b. Potency c. Bioavailability d. Area under the curvearrow_forward
- Triethylenemelamine (TEM) is an antitumor agent. Its activity is due to its ability to cross-link DNA. a. Explain why it can be used only under slightly acidic conditions.b. Explain why it can cross-link DNA.arrow_forwardComplete each Lewis structure, draw all important resonance structures, predict a value for thebond angles requested, and explain your reasoning. a. Nitrous acid (HNO2)HONOHON=ONO= b. Enolate ion (C2H3O) HC1C2=HC2C1=arrow_forwardInstructions: Give an acceptable name for eachester. A. CH, CH2)CO,CH, B. COCHỊCH, C. CH₂CH₂CH₂CH₂COOCH₂CH₂CH₂ Instructions: Give the structure corresponding to each name. a. propyl propanoate b. butyl acetate c. ethyl hexanoate d. methyl benzoate Instructions: Give an acceptable name for each amide A. CH₂CH₂CH₂CH₂ NH₂ Instructions: Draw the structure of each amide. A. N,N-dimethylacetamidearrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning