Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 2, Problem 37P
Is the disease shown in the following pedigree caused by a dominant or a recessive allele? Why? Based on this limited pedigree, do you think the disease allele is rare or common in the population? Why?
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Using the pedigree chart, explain:
a) The number of generations seen.
b) If all blue-coloured shapes are affected with disease X-
how many males are affected?
how many females are affected?
c) Does this disease have a dominant or recessive inheritance pattern? Justify your answer.
Cystic fibrosis (CF) is an autosomal recessive trait. A three-generation pedigree is shown below for a family that carries the mutant allele for cystic fibrosis. Note that carriers are not colored in to allow you to figure out their genotypes. Normal allele = F CF mutant allele = f
What is the genotype of individual #13?
A) ff
B) FF
C) Ff
D) it is impossible to tell
In pedigrees, individuals are usually specified by using a Roman numeral for their generation in the chart and an Arabic number for their position (reading left to right) within that generation. If we use the letter c for the allele that causes cystic fibrosis, what are the genotypes of individuals III-3 and III-4 (the third and fourth individuals shown in generation III) in the pedigree that shows this disease?
Chapter 2 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 2 - For each of the terms in the left column, choose...Ch. 2 - During the millennia in which selective breeding...Ch. 2 - Describe the characteristics of the garden pea...Ch. 2 - An albino corn snake is crossed with a...Ch. 2 - Two short-haired cats mate and produce six...Ch. 2 - Piebald spotting is a condition found in humans in...Ch. 2 - As a Drosophila research geneticist, you keep...Ch. 2 - A mutant cucumber plant has flowers that fail to...Ch. 2 - In a particular population of mice, certain...Ch. 2 - In humans, a dimple in the chin is a dominant...
Ch. 2 - Among Native Americans, two types of earwax...Ch. 2 - Imagine you have just purchased a black stallion...Ch. 2 - If you roll a die singular of dice, what is the...Ch. 2 - Prob. 14PCh. 2 - How many genetically different eggs could be...Ch. 2 - What is the probability of producing a child that...Ch. 2 - Prob. 17PCh. 2 - Galactosemia is a recessive human disease that is...Ch. 2 - Albinism is a condition in which pigmentation is...Ch. 2 - A cross between two pea plants, both of which grew...Ch. 2 - A third-grader decided to breed guinea pigs for...Ch. 2 - The self-fertilization of an pea plant produced...Ch. 2 - Prob. 23PCh. 2 - A pea plant from a pure-breeding strain that is...Ch. 2 - Prob. 25PCh. 2 - A pea plant heterozygous for plant height, pod...Ch. 2 - In the fruit fly Drosophila melanogaster, the...Ch. 2 - Prob. 28PCh. 2 - Considering the yellow and green pea color...Ch. 2 - Prob. 30PCh. 2 - Prob. 31PCh. 2 - Prob. 32PCh. 2 - For each of the following human pedigrees,...Ch. 2 - Consider the pedigree that follows for cutis laxa,...Ch. 2 - A young couple went to see a genetic counselor...Ch. 2 - Huntington disease is a rare fatal, degenerative...Ch. 2 - Is the disease shown in the following pedigree...Ch. 2 - Figure 2.22 shows the inheritance of Huntington...Ch. 2 - Prob. 39PCh. 2 - People with nail-patella syndrome have poorly...Ch. 2 - Midphalangeal hair hair on top of the middle...Ch. 2 - A man with Huntington disease he is heterozygous...Ch. 2 - Explain why disease alleles for cystic fibrosis CF...
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- This pedigree traces the inheritance of a trait in humans. Based on this pedigree, is the allele for this disease dominant or recessive? Is it sex-linked? Explain. What genotypes are most probable for the individuals labeled 4, 7, and 10?arrow_forwardThe following pedigree shows the pattern of inheritance for an uncommon human disease. Filled symbols indicate individuals with the disease: open symbols indicate normal individuals. Using the symbols A and a, answer the following questions about this pedigree. 1. What are the most probable genotypes of individuals II-9 and II-10 2. If individuals II-1 and II-2 have another child, what is the probability that it will have the disease?arrow_forwardIn this case a family history revealed a genetic basis for the disorder. The pedigree is shown in Fig. 1 Below. Key Ø Female: affected Female: unaffected || IV V 5600 orize 077808 15 10 9 10 CHO વ Male: affected Male: unaffected Deceased Disease status not given Dizygotic twins Monozygotic twins Fig. 1 Disease pedigree. Five generations I, II, III, IV, V are shown. Females are represented by circles, males by squares, dizygotic (non-identical) twins by diagonal lines originating from the same point, Monozygotic (identical) twins by diagonal lines originating from the same point and joined symbols and deceased by a diagonal line through the symbol. Filled symbols indicate that the individual displays the disease phenotype. Unfilled symbols indicate that the individual does not display the disease phenotype. Carriers of the disease are not indicated. Information on disease status is not known for generation I and is omitted for the individuals represented by a symbol with an asterisk.…arrow_forward
- The pedigree shows a family in which several members have suffered from one and the same disease (look at the picture to be able to answer) a) Is it a dominant or recessive allele that causes the disease? Motivate your answer. b) Is allele autosomal or sex-linked? Motivate your answer. c) What is the probability that III-3 and III-4 will have a healthy child? Motivate your answer.arrow_forwardTay-Sachs is a recessive lethal disease in which there is neurological deterioration early in life. This disease is rare in the population overall but is found at relatively high frequency in Ashkenazi Jews from Eastern Europe. A woman has a maternal uncle who had the disease. Her father does not come from a high-risk population. Her husband’s sister died of the disease at an early age. Draw the pedigree of the individuals described. Include the genotypes where possible.arrow_forwardRed-green color blindness is inherited as an X-linked recessive (Xc). If a color-blind man marries a woman who is heterozygous for normal vision, what would be the expected phenotypes of their children with reference to this character? In your answer, specify in your phenotype descriptions the gender of the children. (For example, don’t just say 75% of the children would be colorblind – you would instead say 100 % of the daughters would be colorblind and 50% of the sons would be colorblind. Note that this is not a correct answer; it is just to give you an idea of how to explain the correct phenotypes of the cross.)___arrow_forward
- A research team genotyped hundreds of families affected by haemophilia. Among those families, they found many that had a pattern of RFLP like that of daughter1, her husband and her parents. When they genotyped the children in those families, they found the following association between the RFLP and hemophilia: The numbers at the bottom indicate the number of progeny with that combination of hemophilia phenotype and RFLP polymorphism found among these families. What is the map distance between the RFLP and the hemophilia gene? Show your work.arrow_forwardThe attached image is a pedigree of a family with a history of sickle cell anemia (the individuals with the filled-in symbols have the disease and no new mutations are occurring in any individual). Sickle cell anemia is inherited in an autosomal recessive manner. What is the probability that the individual with the question mark (?) will get the disease? a) 1/4 b) 1/2 c) 2/3 d) 1arrow_forwardThe pedigree below shows three generations of a family that carries albinism, an autosomal recessive genetic disease. In the third generation, a child was born with albinism but the genotypes of the rest of the family are unknown. No other family members have the disease. Assume normal, Mendelian genetics with no new mutations. What are the genotypes of the parents of the affected child? A) There is not enough information to determine their genotypes B) Both are homozygous for albinism C) One is hemizygous and one is heterozygous for albinism D) Both are heterozygous for albinism E) One is homozygous and one is heterozygous for abinismarrow_forward
- The pedigree below shows the inheritance of the rare blistering disease (epidermolysis) in dogs. Affected individuals are indicated in black, and those not showing symptoms (phenotypically normal) of the disease in white. The pedigree below represents an autosomal recessive disease. What characteristic(s) of the pedigree supports this statement? Number the generations and individuals in this pedigree. Write the genotypes and their genotype probabilities for all the individuals in the pedigree. Use E/eas the allele symbols.arrow_forwardIn man, muscular dystrophy is a condition in which the muscles waste away during early life and may result in a shorter life expectancy. It is due to a sex-linked, recessive gene. A certain couple has five children – three boys (ages 1yr, 3yrs, and 10yrs old) and two girls (ages 5yrs and 7yrs old). The oldest boy shows the symptoms of this disease. You are their family physician and they come to you for advice. What would you tell them about the chances of their other children developing the disease?arrow_forwardThe following pedigree shows the pattern of inheritance of red-green color blindness in a family. Females are shown as circles and males as squares; the squares or circles of individuals affected by the trait are filled in black. What is the chance that a son of the third-generation female indicated by the arrow will be color blind if the father is not color blind? If he is color blind?arrow_forward
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