EBK GENETICS: FROM GENES TO GENOMES
EBK GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260041255
Author: HARTWELL
Publisher: MCGRAW HILL BOOK COMPANY
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Chapter 20, Problem 15P
Summary Introduction

Introduction:

Cancer is referred to a group of diseases that are caused by abnormal cell proliferation with the ability to spread in different parts of the body. Several types of cancer result in the rapid growth of cells, whereas other types of cancer make cells to grow at a slower rate.

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Which of the following associated with cancer development would you expect to be tumor promoters and not genotoxic carcinogens (select all that apply)?   A. Excessive alcohol consumption that kills liver cells   B. Bisphenol A which mimics the activity of estrogen   C. Chemical in pesticides that binds and activates a transcription factor that cause activation of NFkB   D. Chemical in cigarette smoke that forms adduct with DNA   E.   A viral infection that causes ulcerative coilitis of GI tract
Which of the following steps are correct about multistep tumorigenesis (select all that apply)?   A. Mutations in progenitor cells are more likely to develop a neoplastic state compared to mutations in stem cells   B. Driver mutations give a cell clone a proliferative advanage   C. The rate of mutation /genetic change is constant during tumor progression   D. Nutrition/diet may effect rate of tumorigenesis   E. All cells within a tumor are biologically equivalent and equally capable of high levels proliferation
Researchers have identified some tumors that have no recurrent mutations or deletions in known oncogenes or tumor-suppressor genes and no detectable epigenetic alterations. However, these tumors often have large chromosomal deletions. What are some possible explanations that could account for the genetic causes behind these tumors?

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EBK GENETICS: FROM GENES TO GENOMES

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