![EBK GENETICS: FROM GENES TO GENOMES](https://www.bartleby.com/isbn_cover_images/9781260041255/9781260041255_largeCoverImage.jpg)
EBK GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260041255
Author: HARTWELL
Publisher: MCGRAW HILL BOOK COMPANY
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 20, Problem 4P
Summary Introduction
To determine:
Whether the views regarding germ-line mutations and environmental factors as the cause of cancer conflicting or can be reconciled.
Introduction:
Any abnormal change in the gene sequence is known as mutation. Mutations can lead to various ailments, including cancer. Mutations can lead to uncontrollable growth of the cells leading to the development of cancer.
Expert Solution & Answer
![Check Mark](/static/check-mark.png)
Want to see the full answer?
Check out a sample textbook solution![Blurred answer](/static/blurred-answer.jpg)
Students have asked these similar questions
Describe two mechanisms by which genetic change causes cancer.
Despite all that we know about cancer today, some types of cancers are still increasing in frequency. Lung cancer among nonsmoking women is one of these. What reason(s) might there be for this increasing problem?
Which genetic cancer predisposition syndrome is caused by germ-line mutations in the p53 gene
and is associated with the early onset of cancers and the development of multiple malignant lesions
of diverse tissue origins?
Chapter 20 Solutions
EBK GENETICS: FROM GENES TO GENOMES
Ch. 20 - For each of the terms in the left column, choose...Ch. 20 - Characterize the differences between tumor cells...Ch. 20 - Prob. 3PCh. 20 - Prob. 4PCh. 20 - A carcinogenic compound is placed on the skin of...Ch. 20 - You have decided to study genetic factors...Ch. 20 - B cells are specialized blood cells that secrete...Ch. 20 - Molecules outside and inside the cell regulate the...Ch. 20 - Put the following steps in the correct ordered...Ch. 20 - a. Would you expect a cell to continue or to stop...
Ch. 20 - Two different protein complexes called SCF and APC...Ch. 20 - One of the hallmarks of mitotic anaphase is the...Ch. 20 - Concerning the Tools of Genetics Box Analysis of...Ch. 20 - Are genome and karyotype instabilities...Ch. 20 - Prob. 15PCh. 20 - Why dont all loss-of-function mutations that are...Ch. 20 - Chromothripsis is a rare phenomenon, first...Ch. 20 - The chromosome 9/22 translocation associated with...Ch. 20 - A female patient 19 years old, whose symptoms are...Ch. 20 - Prob. 20PCh. 20 - A generic signaling cascade is shown in the...Ch. 20 - Neurofibromatosis type 1 NF1; also known as von...Ch. 20 - Families with germ-line BRCA1 or BRCA2...Ch. 20 - The text explained that retroviruses can cause...Ch. 20 - Hepatocellular carcinoma is the most frequent form...Ch. 20 - Suppose that instead of microarrays, you analyzed...Ch. 20 - Prob. 27PCh. 20 - Glioblastoma multiforme GBM is the most common and...Ch. 20 - a. The legend to Fig. 20.29 identifies which of...Ch. 20 - The website CBioPortal http://www.cbioportal.org...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Explain the molecular mechanisms of cancers caused by a P53 gene mutation.arrow_forwardWhat is meant by the "two-hit" model of cancer development? Describe this theory in detail and explain why this makes sense with the observation that cancer is typically seen in people who are >60 years of age.arrow_forwardWhat are the heritable changes in cells that contribute to cancer development?arrow_forward
- There are three broad categories of cancer-related genes: proto-oncogenes, tumor suppressor genes, and DNA stability/repair genes. Define each of these categories and indicate which one you think the RB1 gene belongs to and why.arrow_forwardDistinguish between proto-oncogenes and tumor-suppressor genes. To become cancer promoting, do proto-oncogenes and tumor-suppressor genes undergo gain-of-function or loss-of-function mutations? Classify the following genes as proto-oncogenes or tumor-suppressor genes: p53, ras, BCL-2, JUN, MDM2, and p16.arrow_forwardAlthough cancer is not a contagious disease in humans or other vertebrates, there have been rare cases in which cancers have spread from one organism to another. Describe three cases of these contagious cancers and what conditions might have led to their appearance. For an introduction to this topic, see http:// www.cancer.org/cancer/cancerbasics/is-cancer-contagious.arrow_forward
- What separates cancer cells from normal cells? Describe one form of mutation that can increase the risk of a normal cell being cancerous.arrow_forwardPlease discuss the difference between cancers caused by tumor viruses and cancers caused by oncogenes. Does the etiology of a cancer influence its manifestation?arrow_forwardWith regard to cancer cells, which of the following are true? A. Cancer cells are clonal, meaning that they are derived from many different cells that all underwent the same clonal mutation. Cells usually accumulate many mutations over time, and this results in cancerous growth. B. Almost all cancers are caused by oncogenic viruses. no Benign tumors are dangerous because they can easily invade surrounding tissue and spread to other locations in the body. DE. Cancer cells are unable to control their division.arrow_forward
- What is cancer? What defects are commonly found in cancer cells? Do all cancer cells have mutations in the same genes? Explain.arrow_forwardWhat are Ras protein and p53? How can mutations in the genes for these proteins contribute to cancer?arrow_forwardIn Metastatic Breast Cancer [such as in Breast Invasive Ductal Carcinoma; Breast Invasive Carcinoma, NOS; Breast Invasive Cancer, NOS; Invasive Breast Carcinoma; Breast Invasive Lobular Carcinoma; Breast Mixed Ductal and Lobular Carcinoma] what role does the genes Tp53 and Tp63 have? Would one of them affect the other (i.e. mutation, etc) or there is not relationship among the two genes at all.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
![Text book image](https://www.bartleby.com/isbn_cover_images/9781305251052/9781305251052_smallCoverImage.gif)
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
An Introduction to the Human Genome | HMX Genetics; Author: Harvard University;https://www.youtube.com/watch?v=jEJp7B6u_dY;License: Standard Youtube License