Genetic Analysis: An Integrated Approach (3rd Edition)
Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 20, Problem 22P

Tay-Sachs disease is an autosomal recessive neurological disorder that is fatal in infancy. Despite its invariably lethal effect, Tay Sachs disease occurs at very high frequency in some Central and Eastern European (Ashkenazi) Jewish populations. In certain Ashkenazi populations, 1 in 750 infants has Tay Sachs disease. Population biologists believe the high frequency is a consequence of genetic bottlenecks caused by pogroms (genocide) that have reduced the population multiple times in the last several hundred years.

a. What is a genetic bottleneck?

b. Explain how a genetic bottleneck and its aftermath could result in a population that carries a lethal allele in high frequency

c. In the population described, what is the frequency of the recessive allele that produces Tay Sachs disease?

d. Assuming mating occurs at random in this population, what is the probability a couple are both carriers of Tay Sachs disease?

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Chapter 20 Solutions

Genetic Analysis: An Integrated Approach (3rd Edition)

Ch. 20 - Figure 20.6 illustrates the effect of an ethanol ...Ch. 20 - 20.12 Biologists have proposed that the use of...Ch. 20 - 20.13 Two populations of deer, one of them large...Ch. 20 - 20.14 Directional selection presents an apparent...Ch. 20 - 20.15 What is inbreeding depression? Why is...Ch. 20 - 20.16 Certain animal species, such as the...Ch. 20 - Genetic Analysis 20.1 predicts the number of...Ch. 20 - 20.18 In a population of rabbits, and . The...Ch. 20 - Sickle cell disease (SCD) is found in numerous...Ch. 20 - 20.20 Epidemiologic data on the population in the...Ch. 20 - The frequency of tasters and nontasters of PTC...Ch. 20 - Tay-Sachs disease is an autosomal recessive...Ch. 20 - 20.23 Cystic fibrosis (CF) is the most common...Ch. 20 - 20.24 In the mouse, Mus musculus, survival in...Ch. 20 - 20.25 In a population of flowers growing in a...Ch. 20 - Assume that the flower population described in the...Ch. 20 - 20.27 ABO blood type is examined in a Taiwanese...Ch. 20 - 20.28 A total ofmembers of a Central American...Ch. 20 - 20.29 A sample offield mice contains individuals...Ch. 20 - Prob. 30PCh. 20 - Albinism, an autosomal recessive trait...Ch. 20 - 20.32 The frequency of an autosomal recessive...Ch. 20 - 20.33 Evaluate the following pedigree, and answer...Ch. 20 - Evaluate the following pedigree, and answer the...Ch. 20 - The following is a partial pedigree of the British...Ch. 20 - Draw a separate hypothetical pedigree identifying...Ch. 20 - Prob. 37PCh. 20 - 20.38 Achromatopsia is a rare autosomal recessive...Ch. 20 - 20.39 New allopolyploid plant species can arise by...
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