(a)
Interpretation:
The reagent has to be proposed for the conversion of A to B.
Concept introduction:
Michael reaction:
The nucleophile is reaction with α,β-unsaturated carbonyl compound (1,4 –addtion) which yield the addition product is called Michael reaction.
(b)
Interpretation:
The reagent has to be proposed for the conversion of B to C.
Concept introduction:
Reduction:
(c)
Interpretation:
The reagent has to be proposed for the conversion of C to D.
Concept introduction:
Chlorination: Alcohols reaction with thionyl chloride gives chlorinated compound.
(d)
Interpretation:
The mechanism has to be proposed for the conversion of E to F and the formation of methyl chloride has to be shown through mechanism.
(e)
Interpretation:
The reagent has to be proposed for the conversion of F to Fluoxetine.
Concept introduction:
Hydrolysis: Amide undergoes hydrolysis using base like sodium hydroxide gives acid.
(f)
Interpretation:
The possible stereoisomer’s has to be shown if the product is chiral.
Concept introduction:
Chiral:
A molecule is non superimposable on its mirror image is called chiral molecule.
Four different atoms attached to a carbon atom is called chiral molecule.
Isomer: A molecule having the same molecular formula but with different chemical structure is called isomer.
Stereoisomers: Stereoisomers are molecules that have the same molecular formula and they differ only in arrangement of atom in three-dimensional space.
Enantiomers: A compound which is non-superimposable mirror image is called enantiomers.
Diastereomers: A compound which is non-superimposable and non-mirror image is called diastereomers.
Racemic mixture: A racemic mixture is simply a mixture containing an equal amount of each enantiomer.
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Organic Chemistry
- Suggest a suitable mechanism for this multi-step reaction, and give products A and Barrow_forwardPropose a synthesis pathway for the production of the following compounds (d) to (e) from the given starting materials plus necessary organic and inorganic reagents.arrow_forwardProvide a mechanism for the following transformationarrow_forward
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- propose a mechanism for the following transformationsarrow_forwardPropose a synthesis for the following transformationarrow_forwardThe ketone shown was prepared in a three-step sequence from ethyl trifluoroacetate. The first step in the sequence involved treating ethyl trifluoroacetate with ammonia to give compound A. Compound A was in turn converted to the desired ketone by way of compound B. Fill in the missing reagents in the sequence shown, and give the structures of compounds A and B.arrow_forward
- Propose a mechanism for the reaction of benzyl acetate with methylamine. Label theattacking nucleophile and the leaving group, and draw the transition state in which theleaving group leaves.arrow_forwardDevise a concise synthesis for the following transformations. Clearly show the reagent and productfor each step. Each synthesis can be accomplished in two steps except for d, which requires three steps.arrow_forwardExplain in detail which of the following compounds (A or B) when reacted with acetophenone under basic conditions will undergo a 1,4 addition reaction. Predict the product of the reaction and propose a mechanism.arrow_forward
- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning