Interpretation: The reason corresponding to the fact that organolithium reagents are not used to generate enolates is to be stated.
Concept Introduction: The substitution reaction involves the replacement of one
The nucleophilic reaction that consists of bimolecular as well as bond-making and bond-breaking steps is termed as
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ORGANIC CHEMISTRY-ACCESS
- Modify the given structure and the product formed.arrow_forwardExplain why a methoxy group (CH3O) increases the rate of electrophilic aromatic substitution, but decreases the rate of nucleophilic aromatic substitution.arrow_forwardAcetal formation must be catalyzed by an acid. Explain why it cannot be catalyzed by CH3O-.arrow_forward
- Why do you wash the dichloromethane solution of your reductive amination product with sodium bicarbonate, rather than dilute aqueous HCl? a) Sodium bicarbonate is a good method of removing aldehydes from organic solvent.b) The amine product will be protonated by acid and remain in the aqueous layer as a salt.c) Sodium bicarbonate transfers the amine starting material into the aqueous layer.d) Sodium bicarbonate reacts with leftover NaBH(OAc)3 and removes it from the mixture.arrow_forwardb) The Wolf-Kishner reduction is a reaction used in Organic Chemistry to convert carbonyl functionalities into methylene group. The reaction was used to convert an aldehyde or ketone to an alkane using hydrazine, base and thermal conditions. The mechanism begins with the attack of hydrazine of the aldehyde or ketone. Stage 1: The reaction of aldehyde/ketone with hydrazine to produce hydrazine Stage 2: Reaction with the base and heat to convert hydrozone to alkane Write the mechanism of the reaction.arrow_forwardPlease give the appropriate reagents to complete the following synthesis.arrow_forward
- Which of the following could act as a nucleophile? A) HCl B) CH3NH2 C) BF3 D) CH3Brarrow_forward20:32 hydroxide 2. Using curved arrows, show the deprotonation mechanism of phenol with (OH). Also, provide the structure of the product of this deprotonation. Start answering this question by drawing the structure of phenol. Then hydroxide ion. Find your most reactive electrons and draw the curved arrow that shows where they would go to deprotonate phenol. Then "make a bond break a bond" write they question 3. Provide valid resonance structures for the product of the previous arrow(s) charge moving onto the ortho- and para positions. Use curved to show how the charge resonates to the next structure in your scheme. all the proper notations for depicting resonance. that show the in the structures Be sure to use Send a chat Carrow_forward2 H3C H3C H C→XT OH H3C The aldol reaction is a carbonyl condensation reaction between two carbonyl partners and involves a combination of nucleophilic addition and a-substitution steps. One partner is converted into an enolate ion nucleophile and adds to the electrophilic carbonyl group of the second partner. In the classic aldol reaction, the carbonyl partners are aldehydes or ketones, although aldehydes are more reactive. The product is a ß-hydroxy carbonyl compound. base :0: OH H H Under reaction conditions slightly more vigorous than those employed for the aldol reaction, the ß-hydroxyl group is eliminated in an E1cB dehydration to give an a,ß-unsaturated carbonyl compound. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instruct ns H3C heat OH H3C :0: H + H₂O Harrow_forward
- The Stork reaction is a condensation reaction between an enamine donor and an α,β-unsaturated carbonyl acceptor. The overall reaction consists of a three-step sequence of formation of an enamine from a ketone, Michael addition to an α,β-unsaturated carbonyl compound, and hydrolysis of the enamine in dilute acid to regenerate the ketone. Consider the Stork reaction between cyclohexanone and propenal Draw the structure of the product of the enamine formed between cyclohexanone and dimethylamine. - Michael addition to an α,β-unsaturated carbonyl compound, and - hydrolysis of the enamine in dilute acid to regenerate the ketone.arrow_forwardIn a reaction between a certain alkyl halide and sodium cyanide, it was found that decreasing the alkyl halide concentration by one half, the rate of the reaction decreased by one half. Which of the following is a reasonable conclusion based on this information? b) The reaction proceeds by the E1 mechanism. c) The reaction proceeds by the SN2 mechanism. a) The reaction proceeds by the SN1 mechanism. d) The reaction proceeds by the E2 mechanism. e) None of these is a reasonable conclusion.arrow_forwardFor the Reaction: NH3+ H2O = NH4+ OH- When adding NH3+ phenolphthalien+ HCl What stress is applied and what direction does the equilibrium shift? When adding NH3+ phenolphthalien+ NH4Cl What stress is applied and what direction does the equilibrium shift? When adding NH3+ phenolphthalien+ NaOH What stress is applied and what direction does the equilibrium shift? When adding NH3+ phenolphthalien+ HCl What stress is applied and what direction does the equilibrium shift?arrow_forward
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