Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 22, Problem 10CONQ
As described in Chapter 5, not all inherited traits are determined by nuclear genes (i.e., genes located in the cell nucleus) that are expressed during the life of an individual. In particular, maternal effect genes and mitochondrial DNA are notable exceptions. With these ideas in mind, let’s consider the cloning of a sheep (e.g., Dolly).
A. With regard to maternal effect genes, is the
B. Does the cloned animal inherit extranuclear traits from the animal that donated the egg or from the animal that donated the somatic cell? Explain.
C. In what ways would you expect this cloned animal to be similar to or different from the animal that donated the somatic cell? Is it accurate to call such an animal a “clone” of the animal that donated the nucleus?
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Chapter 22 Solutions
Genetics: Analysis and Principles
Ch. 22.1 - 1. Which of the following uses of microorganisms...Ch. 22.1 - Prob. 2COMQCh. 22.1 - Prob. 3COMQCh. 22.2 - When a cloned gene is inserted into a noncritical...Ch. 22.2 - Prob. 2COMQCh. 22.3 - Prob. 1COMQCh. 22.3 - Prob. 2COMQCh. 22.4 - Prob. 1COMQCh. 22.4 - Prob. 2COMQCh. 22.5 - A means of introducing a cloned gene into cells...
Ch. 22.5 - 2. Which of the following best describes the...Ch. 22 - 1. What is a recombinant microorganism? Discuss...Ch. 22 - Prob. 2CONQCh. 22 - 3. What is bioremediation? What is the difference...Ch. 22 - Prob. 4CONQCh. 22 - Prob. 5CONQCh. 22 - Prob. 6CONQCh. 22 - 7. What is a transgenic organism? Describe three...Ch. 22 - Prob. 8CONQCh. 22 - Explain the difference between gene modification...Ch. 22 - As described inChapter 5, not all inherited traits...Ch. 22 - Prob. 11CONQCh. 22 - 12. Discuss the concerns that some people have...Ch. 22 - Prob. 1EQCh. 22 - 2. Bacillus thuringiensis makes toxins that kill...Ch. 22 - Prob. 3EQCh. 22 - Prob. 4EQCh. 22 - Prob. 5EQCh. 22 - What is a gene knockout? Is an animal or plant...Ch. 22 - Prob. 7EQCh. 22 - Evidence [see P. G. Shiels, A. J. Kind, K. H....Ch. 22 - Prob. 9EQCh. 22 - 10. What is reproductive cloning? Are identical...Ch. 22 - Researchers have identified a gene in humans that...Ch. 22 - Treatment of adenosine deaminase (ADA) deficiency...Ch. 22 - Several research studies are under way that...Ch. 22 - Prob. 1QSDCCh. 22 - 2. A commercially available strain of P....Ch. 22 - Prob. 3QSDC
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- Not all inherited traits are determined by nuclear genes (i.e., genes located in the cell nucleus) that are expressed during the life of an individual. In particular, maternal effect genes and mitochondrial DNA are notable exceptions. With these ideas in mind, let’s consider the cloning of a sheep (e.g., Dolly). A. With regard to maternal effect genes, is the phenotype of such a cloned animal determined by the animal that donated the enucleatedegg or by the animal that donated the somatic cell nucleus? Explain.arrow_forwardMice usually have wild-type agouti fur that appears grey, but a mouse geneticist has a pure-breeding white-furred strain that is homozygous for a recessive mutation. Molecular analysis shows that the mutation is a missense mutation in an exon common to three alternatively spliced forms of a gene expressed in hair follicles. Which of the following transgenic animals would be most useful to determine which spliced form (or forms) is sufficient to specify agouti fur?A. Construct a GFP reporter using the promoter for the identified gene. B. Express a wild-type version of a cDNA for each spliced form in the white mutant mouse to see which form(s) rescue the phenotype. C. Use CRISPR/Cas9 to make a large deletion of the entire coding region of the identified gene. D. Introduce the wild-type genomic allele into the mutant mouse to test for rescue of the mutant phenotypearrow_forwardWhen disrupting a mouse gene by knockout, why is it desirable to breed mice until offspring homozygous (-/-) for the knockout target gene are obtained?arrow_forward
- A wild type strain of Drosophila was found to carry a transposable element called copia.From this strain (red eyed), a white-eyed strain was obtained in which the copia element hadtransposed to a region on the X-chromosome that corresponded to where the eye-color genemapped. How would you clone the eye-color gene and confirm your discovery?arrow_forwardGeneticists often use ethylmethane sulfonate (EMS) to induce mutations in Drosophila. Why is EMS a mutagen of choice for genetic research? What would be the effects of EMS in a strain of Drosophila lacking functional mismatch repair systems?arrow_forwardNext-generation sequencing reveals that six new mutations have occurred in the coding regions of genes in an individual diploid fly. If the coding regions of this fly comprise 100 million nucleotides per haploid genome, what is the mutation rate per nucleotide?arrow_forward
- In this module, you have learned about the use of balancer chromosomes (such as TM2 and TM6C in the below crossing scheme) for isolating Drosophila mutants during EMS mutagenesis. Please inspect the following crossing scheme and choose which of the following statements is correct. A. TM6C is preferable over TM2 when performing mutagenesis B. EMS induces chromosomal inversion C. A balancer chromosome helps to isolate on which chromosome the mutant is located D. Following the above crossing scheme all flies with no TM2 or TM6C markers are mutantsarrow_forwardAs shown in Figure 13-14, what is the fundamental distinction between a pair-rule gene and a segment-polaritygene?arrow_forwardDiscuss the differences between transposable elements that are genomic parasites and transposable elements that have become domesticated. Do you think these terms (genomic parasite and domesticated transposable elements) are good choices for these types of elements? Why or why not?arrow_forward
- in the cloning vector, what would be the plausible impacts if a mutation at the Ori site renders it non- functional?arrow_forwardCystic fibrosis can arise from a rare, short, in-frame deletion within the CFTR gene, whichcreates a recessive, disease-causing allele. Using this information, describe a PCRexperiment that could be undertaken to determine whether a healthy individual is acarrier of the cvstic-fibrosis mutation.arrow_forward. Early in development, most human cells turn off expression of an essential component of telomerase, the enzyme responsible for addition of telomere repeat sequences (5’-TTAGGG) to the ends of chromosomes. Thus, as our cells proliferate their telomeres get shorter and shorter, but are normally not lost over the course of a lifetime. If cells are removed from the body and grown in culture, however they ultimately enter a state of replicative senescence and stop dividing when their telomeres get too short. By contrast, most human tumor cells express active telomerase, allowing them to maintain their telomeres and grow beyond the normal limit imposed by senescence - good for them, bad for us. Anticipating a universal cure for cancer, you set up a company to screen chemical ‘libraries’ for telomerase inhibitors. The company share price takes a dive, however, when a rival group generates a strain of telomerase-knockout mice. These mice breed happily for several generations, but…arrow_forward
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