Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 23, Problem 13P
Interpretation Introduction
Interpretation:
A reasonable mechanism for HMG-CoA synthase reaction should be written.
Concept Introduction:
Acetyl CoA produced by ß oxidation of fatty acids undergoes further oxidation in the TCA cycle. Some of this acetyl CoA is converted into three metabolites; acetone, acetoacetate and ß hydroxybutyrate. Process of formation of these metabolites is known as ketogenesis. Although ß hydroxybutyrate does not have a
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Chapter 23 Solutions
Biochemistry
Ch. 23 - Prob. 1PCh. 23 - Determining the Amount of ATP Produced from Fatty...Ch. 23 - Prob. 3PCh. 23 - Examining the Labeling of Glucose from 14C.labeled...Ch. 23 - Prob. 5PCh. 23 - Prob. 6PCh. 23 - Prob. 7PCh. 23 - Prob. 8PCh. 23 - Prob. 9PCh. 23 - Prob. 10P
Ch. 23 - Prob. 11PCh. 23 - Understanding Human Energy Consumption During...Ch. 23 - Prob. 13PCh. 23 - Prob. 14PCh. 23 - Prob. 15PCh. 23 - Extending the Mechanism of Methylmalonyl-CoA...Ch. 23 - Prob. 17PCh. 23 - Prob. 18PCh. 23 - Prob. 19PCh. 23 - Understanding a Ubiquitous Series of Metabolic...Ch. 23 - Using the ActiveModel for enoyl-CoA dehydratase,...
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- Understanding the Mechanism of the HMC-CoA Synthase Reaction Write a suitable mechanism for the HMG-CoA synthase reaction. What is the chemistry that drives this condensation reaction?arrow_forwardComplete oxidation of a 16-carbon fatty acid can yield 129 molecules of ATP Study Figure 19.2 and determine how many ATP molecules would be generated if a 16-carbon fatly acid were metabolized solely by the TCA cycle, in the form of S acetyl-CoA molecules.arrow_forwardExtending the Mechanism of Methylmalonyl-CoA Mutase to Similar Reactions Based on the mechanism for the methylmalonyl-CoA mutase (see problem 14), write reasonable mechanisms for the following reactions shown.arrow_forward
- Calculate the number of ATPs generated from the metabolic oxidation of the four carbons of acetoacetyl-CoA to CO2. Now consider the homolog derived from oxidation of an odd-numbered carbon chain, namely, propionoacetyl- CoA. Calculate the net ATP yield from oxidation of the five carbons of this compound to CO2.arrow_forwardCalculate the number of ATPs generated from the metabolic oxidation of the four carbons of acetoacetyl-CoA to CO2. Now consider the homolog derived from oxidation of an odd-numbered carbon chain, namely, propionoacetyl-CoA. Calculate the net ATP yield from oxidation of the five carbons of this compound to CO2.arrow_forwardAnother biochemical study from another patient reveals a 100X increase in the KM value for the enzyme succinyl-CoA synthetase for this individual (only isozyme expressed). What metabolic and physiological consequences would you predict resulting from this enzymatic change?arrow_forward
- In the beta oxidatiin pathway when the starting fatty acid contains n carbons what is the priduct of the enzyme acyl-CoA sythetase assume the starting saturated fatty acud contains n carbons and n is an even numberarrow_forwardCalculate the number of ATP formed from NADH and FADH2. The calculation should be based on the total number of protons and c-subunits of 2-Acetyl-CoA that has 15 subunits.arrow_forwardPyruvate can enter the TCA cycle via two enzymatic reactions. Provide a simplified schematic presentation of the TCA cycle to show this. Also indicate how these reactions are regulated.arrow_forward
- Pharmaceuticals in a class called the statins inhibit theenzyme HMG-CoA reductase. What is the primary effect ofthis drug on patients?arrow_forwardConsidering the complete oxidation of an 18-C fatty acid. Give the answer to the following question.a. What is the total number of NADH produced in TCA if all of the acetyl CoA enters the cycle? b. What is the total number of FADH2 produced in TCA if all the acetyl CoA enters the cycle?c. How much ATP is produced in the overall oxidation?arrow_forwardWhat would be the difference in ATP generated from beta oxidation of a 14C fatty acid with 1 double bond and a 16C fatty acid with two double bonds? Do not calculate atp generated from acetyl CoAarrow_forward
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