Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 23, Problem 14P
Interpretation Introduction
Interpretation:
A reasonable mechanism for the methylmalonyl CoA mutase reaction should be written.
Concept Introduction:
Humans and animals can
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Considering the fatty acids:
(a) Arachidic acid (C20H40O2); molar mass = 312.5 g/mol)
(b) Palmitoleic acid (C16H30O2); molar mass = 256.4 g/mol).
How many cycles of β -oxidation are needed for complete oxidation?
How many molecules of acetyl CoA are formed from its complete catabolism?
How can you calculate the number of molecules (moles) of ATP formed (net) by the complete catabolism of each fatty acid? and the number of moles of ATP formed per gram of each fatty acid metabolized??
Account for the total no. of ATPs produced from β-oxidation for one mole of the given fatty acid (16C). How many acetyl-coA are formed?
Consider docosanoic acid C12H43CO2H
a. Label the alpha and beta Carbons. Show the beta-oxidation in an EXPANDED structure.
b. Draw each acyl CoA derived from this fatty acid.
c. How many acetyl Co A molecules are formed by complete beta-oxidation?
d. How many cycles of beta-oxidation are needed for complete oxidation?
e. How many molecules of ATP are formed from the complete catabolism of this fatty acid? Show the complete computation.
f. How many moles of ATP per gram of fatty acid is formed from the complete catabolism of the given fatty acid?
g. What is the molar mass of the given fatty acid?
Solution: Show here the complete computations, [from a to e]
Chapter 23 Solutions
Biochemistry
Ch. 23 - Prob. 1PCh. 23 - Determining the Amount of ATP Produced from Fatty...Ch. 23 - Prob. 3PCh. 23 - Examining the Labeling of Glucose from 14C.labeled...Ch. 23 - Prob. 5PCh. 23 - Prob. 6PCh. 23 - Prob. 7PCh. 23 - Prob. 8PCh. 23 - Prob. 9PCh. 23 - Prob. 10P
Ch. 23 - Prob. 11PCh. 23 - Understanding Human Energy Consumption During...Ch. 23 - Prob. 13PCh. 23 - Prob. 14PCh. 23 - Prob. 15PCh. 23 - Extending the Mechanism of Methylmalonyl-CoA...Ch. 23 - Prob. 17PCh. 23 - Prob. 18PCh. 23 - Prob. 19PCh. 23 - Understanding a Ubiquitous Series of Metabolic...Ch. 23 - Using the ActiveModel for enoyl-CoA dehydratase,...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Extending the Mechanism of Methylmalonyl-CoA Mutase to Similar Reactions Based on the mechanism for the methylmalonyl-CoA mutase (see problem 14), write reasonable mechanisms for the following reactions shown.arrow_forwardUnderstanding the Oxidation of Glucose and Its Products in the TCA Cycle Glycolysis, the pyruvate dehydrogenase reaction, and the TCA cycle result in complete oxidation of a molecule of glucose to CO2. Review the calculation of oxidation numbers for individual atoms in any molecule, and then calculate the oxidation numbers of the carbons of glucose, pyruvate, the acetyl carbons of acetyl-CoA. and the metabolites of the TCA cycle to convince yourself that complete oxidation of glucose involves removal of 24 electrons and that each acetyl-CoA through the TCA cycle gives up 8 electrons.arrow_forwardUnderstanding Enzyme Mechanisms Related to Pyruvate Carboxylase Based on the mechanism for pyruvate carboxylase (Figure 22.3), write reasonable mechanisms for the reactions that follow:arrow_forward
- Ethanol as a Source of Metabolic Energy (Integrates with Chapters 19 and 20.) Acetate produced in ethanol metabolism can be transformed into acetyl-COA by the acetyl thiokinase reaction: Acetate+ATP+CoASHacetyleCoA+AMP+PPiAcetyle-CoA then can enter the citric acid cycle and undergo oxidation to 2 CO2by this route, assuming oxidative phosphorylation is part of the process? (Assume all reactions prior to acetyl-CoA entering the citric acid cycle occur outside the mitochondrion). Per carbon atom, which is a better metabolic fuel, ethanol or glucose? That is, how many ATP equivalents per carbon atom are generated by combustion of glucose versus ethanol to CO2?arrow_forwardUnderstanding the Mechanism of the 3-ketosphinganine Synthase Reaction Write a reasonable mechanism for the 3-ketosphinganine synthase reaction, remembering that it is a pyridoxal phosphate-dependent reaction.arrow_forwardExplaining the Stoichiometry of Fatty Acid Synthesis Carefully count and account for each of the atoms and charges in the equations for the synthesis of palmitoyl-CoA, the synthesis of malonyl-CoA, and the overall reaction for the synthesis of palmitoyl-CoA from acetyl-CoA.arrow_forward
- The catalytic efficiency of many enzymes depends on pH. Chymotrypsin, which has a well-known catalytic mechanism, shows a maximum value of kcat/Km at pH 8.0. A) Draw a pH curve of chymotrypsin activity over the pH range of 5 to 10 and briefly explain the rationale within the context of catalysis for your depiction. In particular, note how kcat and Km may change over this pH range. B) Enzymes of the a-amylase family catalyze a reaction by forming a covalent intermediate analogous to chymotrypsin, but to a conserved aspartate residue. Illustrate a catalytic mechanism containing a tetrahedral intermediate for a glycogen debranching enzyme based upon its potential membership in the a-amylase family. (don’t need to draw a whole glycogen)arrow_forwardBehenate (C22H44O2) can be obtained by chain elongation from palmitate. How many ATP equivalents are produced in the degradation of behenate to eleven acetyl-CoA?arrow_forward
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