(a) Interpretation: Atoms that are added or removed in each step needs to be determined. Concept Introduction: The citric acid cycle is an eight steps cycle which consists enzyme catalyzed reactions occur in mitochondria. The citric acid cycle starts by the addition of 2 carbon acetyl CoA molecule to four carbon substrate. Acetyl CoA is regenerated at the end of the cycle. In step 2 of citric acid cycle, citrate is converted to isocitrate. This conversion is a two-step process which has an intermediate called aconitate.

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Answer 1

Question

Chapter 23, Problem 23.50P

Interpretation Introduction

(a)

Interpretation:

Atoms that are added or removed in each step needs to be determined.

Concept Introduction:

The citric acid cycle is an eight steps cycle which consists enzyme catalyzed reactions occur in mitochondria. The citric acid cycle starts by the addition of 2 carbon acetyl CoA molecule to four carbon substrate. Acetyl CoA is regenerated at the end of the cycle.

In step 2 of citric acid cycle, citrate is converted to isocitrate. This conversion is a two-step process which has an intermediate called aconitate.

Interpretation Introduction

(b)

Interpretation:

The reason due to which step [2a] and [2b] are not considered oxidation or reduction reactions despite the fact that the number of C-H and C-O bond changes need to be explained.

Concept Introduction:

During oxidation of a compound, electrons or hydrogens are lost or oxygen is gained. During the reduction of a compound, electrons or hydrogens are gained or oxygen is lost. Coenzymes act as oxidizing agents or reducing agents. Oxidizing agent drives the oxidation reaction and gets reduced. Reducing agent drives reduction reactions and gets oxidized.

Interpretation Introduction

(c)

Interpretation:

Type of reaction occurs in step [2a] and [2b] needs to be determined.

Concept Introduction:

The citric acid cycle is an eight steps cycle which consists enzyme catalyzed reactions occur in mitochondria. The citric acid cycle starts by the addition of 2 carbon acetyl CoA molecule to four carbon substrate. Acetyl CoA is regenerated at the end of the cycle.

In step 2 of citric acid cycle, citrate is converted to isocitrate. This conversion is a two-step process which has an intermediate called aconitate.

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There are eight chemical reactions that occur in the citric acid cycle process. The reactions of the citric acid cycle are shown in the figure below. You were introduced to several classes of organic reactions. These classes include esterification, decarboxylation, hydration reactions, dehydration of alcohols, oxidation of alcohols, oxidation of aldehydes, reduction of aldehydes, and reduction of ketones. Find at least one of these reaction classes in the citric acid cycle. List the reaction number and the reaction. Write a sentence or two on how you were able to make the classification.

A portion of the citric acid cycle is shown below. What are the identities of A and B? citrate → A→isocitrate → B A = cis-aconitate; B = a-ketoglutarate A = malate; B = fumarate A = cis-aconitate; B = oxaloacetate A = a-ketoglutarate; B = succinate A = succinate; B = a-ketoglutarate

The rate-limiting step is a metabolic pathway is the slowest step which determines the overall rate of the other reactions in the pathway. In glycolysis, the rate limiting step is a phosphorylation reaction where phosphofructokinase (PFK-1) catalyzes the reaction fructose-6-bisphosphate -> fructose-1,6-bisphosphate, the same step in gluconeogenesis. Select one: The statement is FALSE. The statement is TRUE.

Answer 2

Question

Chapter 23, Problem 23.50P

Interpretation Introduction

(a)

Interpretation:

Atoms that are added or removed in each step needs to be determined.

Concept Introduction:

The citric acid cycle is an eight steps cycle which consists enzyme catalyzed reactions occur in mitochondria. The citric acid cycle starts by the addition of 2 carbon acetyl CoA molecule to four carbon substrate. Acetyl CoA is regenerated at the end of the cycle.

In step 2 of citric acid cycle, citrate is converted to isocitrate. This conversion is a two-step process which has an intermediate called aconitate.

Interpretation Introduction

(b)

Interpretation:

The reason due to which step [2a] and [2b] are not considered oxidation or reduction reactions despite the fact that the number of C-H and C-O bond changes need to be explained.

Concept Introduction:

During oxidation of a compound, electrons or hydrogens are lost or oxygen is gained. During the reduction of a compound, electrons or hydrogens are gained or oxygen is lost. Coenzymes act as oxidizing agents or reducing agents. Oxidizing agent drives the oxidation reaction and gets reduced. Reducing agent drives reduction reactions and gets oxidized.

Interpretation Introduction

(c)

Interpretation:

Type of reaction occurs in step [2a] and [2b] needs to be determined.

Concept Introduction:

The citric acid cycle is an eight steps cycle which consists enzyme catalyzed reactions occur in mitochondria. The citric acid cycle starts by the addition of 2 carbon acetyl CoA molecule to four carbon substrate. Acetyl CoA is regenerated at the end of the cycle.

In step 2 of citric acid cycle, citrate is converted to isocitrate. This conversion is a two-step process which has an intermediate called aconitate.

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Answer 3

Question

Chapter 23, Problem 23.50P

Interpretation Introduction

(a)

Interpretation:

Atoms that are added or removed in each step needs to be determined.

Concept Introduction:

The citric acid cycle is an eight steps cycle which consists enzyme catalyzed reactions occur in mitochondria. The citric acid cycle starts by the addition of 2 carbon acetyl CoA molecule to four carbon substrate. Acetyl CoA is regenerated at the end of the cycle.

In step 2 of citric acid cycle, citrate is converted to isocitrate. This conversion is a two-step process which has an intermediate called aconitate.

Interpretation Introduction

(b)

Interpretation:

The reason due to which step [2a] and [2b] are not considered oxidation or reduction reactions despite the fact that the number of C-H and C-O bond changes need to be explained.

Concept Introduction:

During oxidation of a compound, electrons or hydrogens are lost or oxygen is gained. During the reduction of a compound, electrons or hydrogens are gained or oxygen is lost. Coenzymes act as oxidizing agents or reducing agents. Oxidizing agent drives the oxidation reaction and gets reduced. Reducing agent drives reduction reactions and gets oxidized.

Interpretation Introduction

(c)

Interpretation:

Type of reaction occurs in step [2a] and [2b] needs to be determined.

Concept Introduction:

The citric acid cycle is an eight steps cycle which consists enzyme catalyzed reactions occur in mitochondria. The citric acid cycle starts by the addition of 2 carbon acetyl CoA molecule to four carbon substrate. Acetyl CoA is regenerated at the end of the cycle.

In step 2 of citric acid cycle, citrate is converted to isocitrate. This conversion is a two-step process which has an intermediate called aconitate.

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Answer 4

Question

Chapter 23, Problem 23.50P

Interpretation Introduction

(a)

Interpretation:

Atoms that are added or removed in each step needs to be determined.

Concept Introduction:

The citric acid cycle is an eight steps cycle which consists enzyme catalyzed reactions occur in mitochondria. The citric acid cycle starts by the addition of 2 carbon acetyl CoA molecule to four carbon substrate. Acetyl CoA is regenerated at the end of the cycle.

In step 2 of citric acid cycle, citrate is converted to isocitrate. This conversion is a two-step process which has an intermediate called aconitate.

Interpretation Introduction

(b)

Interpretation:

The reason due to which step [2a] and [2b] are not considered oxidation or reduction reactions despite the fact that the number of C-H and C-O bond changes need to be explained.

Concept Introduction:

During oxidation of a compound, electrons or hydrogens are lost or oxygen is gained. During the reduction of a compound, electrons or hydrogens are gained or oxygen is lost. Coenzymes act as oxidizing agents or reducing agents. Oxidizing agent drives the oxidation reaction and gets reduced. Reducing agent drives reduction reactions and gets oxidized.

Interpretation Introduction

(c)

Interpretation:

Type of reaction occurs in step [2a] and [2b] needs to be determined.

Concept Introduction:

The citric acid cycle is an eight steps cycle which consists enzyme catalyzed reactions occur in mitochondria. The citric acid cycle starts by the addition of 2 carbon acetyl CoA molecule to four carbon substrate. Acetyl CoA is regenerated at the end of the cycle.

In step 2 of citric acid cycle, citrate is converted to isocitrate. This conversion is a two-step process which has an intermediate called aconitate.

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Answer 5

Chapter 23, Problem 23.50P

Interpretation Introduction

(a)

Interpretation:

Atoms that are added or removed in each step needs to be determined.

Concept Introduction:

The citric acid cycle is an eight steps cycle which consists enzyme catalyzed reactions occur in mitochondria. The citric acid cycle starts by the addition of 2 carbon acetyl CoA molecule to four carbon substrate. Acetyl CoA is regenerated at the end of the cycle.

In step 2 of citric acid cycle, citrate is converted to isocitrate. This conversion is a two-step process which has an intermediate called aconitate.

Interpretation Introduction

(b)

Interpretation:

The reason due to which step [2a] and [2b] are not considered oxidation or reduction reactions despite the fact that the number of C-H and C-O bond changes need to be explained.

Concept Introduction:

During oxidation of a compound, electrons or hydrogens are lost or oxygen is gained. During the reduction of a compound, electrons or hydrogens are gained or oxygen is lost. Coenzymes act as oxidizing agents or reducing agents. Oxidizing agent drives the oxidation reaction and gets reduced. Reducing agent drives reduction reactions and gets oxidized.

Interpretation Introduction

(c)

Interpretation:

Type of reaction occurs in step [2a] and [2b] needs to be determined.

Concept Introduction:

The citric acid cycle is an eight steps cycle which consists enzyme catalyzed reactions occur in mitochondria. The citric acid cycle starts by the addition of 2 carbon acetyl CoA molecule to four carbon substrate. Acetyl CoA is regenerated at the end of the cycle.

In step 2 of citric acid cycle, citrate is converted to isocitrate. This conversion is a two-step process which has an intermediate called aconitate.

Answer 6

Chapter 23, Problem 23.50P

Interpretation Introduction

(a)

Interpretation:

Atoms that are added or removed in each step needs to be determined.

Concept Introduction:

The citric acid cycle is an eight steps cycle which consists enzyme catalyzed reactions occur in mitochondria. The citric acid cycle starts by the addition of 2 carbon acetyl CoA molecule to four carbon substrate. Acetyl CoA is regenerated at the end of the cycle.

In step 2 of citric acid cycle, citrate is converted to isocitrate. This conversion is a two-step process which has an intermediate called aconitate.

Answer 7

Chapter 23, Problem 23.50P

Interpretation Introduction

(a)

Interpretation:

Atoms that are added or removed in each step needs to be determined.

Concept Introduction:

The citric acid cycle is an eight steps cycle which consists enzyme catalyzed reactions occur in mitochondria. The citric acid cycle starts by the addition of 2 carbon acetyl CoA molecule to four carbon substrate. Acetyl CoA is regenerated at the end of the cycle.

In step 2 of citric acid cycle, citrate is converted to isocitrate. This conversion is a two-step process which has an intermediate called aconitate.

Answer 8

Interpretation Introduction

(b)

Interpretation:

The reason due to which step [2a] and [2b] are not considered oxidation or reduction reactions despite the fact that the number of C-H and C-O bond changes need to be explained.

Concept Introduction:

During oxidation of a compound, electrons or hydrogens are lost or oxygen is gained. During the reduction of a compound, electrons or hydrogens are gained or oxygen is lost. Coenzymes act as oxidizing agents or reducing agents. Oxidizing agent drives the oxidation reaction and gets reduced. Reducing agent drives reduction reactions and gets oxidized.

Answer 9

Interpretation Introduction

(b)

Interpretation:

The reason due to which step [2a] and [2b] are not considered oxidation or reduction reactions despite the fact that the number of C-H and C-O bond changes need to be explained.

Concept Introduction:

During oxidation of a compound, electrons or hydrogens are lost or oxygen is gained. During the reduction of a compound, electrons or hydrogens are gained or oxygen is lost. Coenzymes act as oxidizing agents or reducing agents. Oxidizing agent drives the oxidation reaction and gets reduced. Reducing agent drives reduction reactions and gets oxidized.

Answer 10

Interpretation Introduction

(c)

Interpretation:

Type of reaction occurs in step [2a] and [2b] needs to be determined.

Concept Introduction:

The citric acid cycle is an eight steps cycle which consists enzyme catalyzed reactions occur in mitochondria. The citric acid cycle starts by the addition of 2 carbon acetyl CoA molecule to four carbon substrate. Acetyl CoA is regenerated at the end of the cycle.

In step 2 of citric acid cycle, citrate is converted to isocitrate. This conversion is a two-step process which has an intermediate called aconitate.

Answer 11

Interpretation Introduction

(c)

Interpretation:

Type of reaction occurs in step [2a] and [2b] needs to be determined.

Concept Introduction:

The citric acid cycle is an eight steps cycle which consists enzyme catalyzed reactions occur in mitochondria. The citric acid cycle starts by the addition of 2 carbon acetyl CoA molecule to four carbon substrate. Acetyl CoA is regenerated at the end of the cycle.

In step 2 of citric acid cycle, citrate is converted to isocitrate. This conversion is a two-step process which has an intermediate called aconitate.

Answer 12

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Answer 13

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Answer 14

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Answer 15

Ch. 23.2 - Prob. 23.1P Ch. 23.3 - Prob. 23.2P Ch. 23.3 - Prob. 23.3P Ch. 23.3 - Prob. 23.4P Ch. 23.3 - Prob. 23.5P Ch. 23.4 - Prob. 23.6P Ch. 23.4 - Prob. 23.7P Ch. 23.4 - Prob. 23.8P Ch. 23.4 - Prob. 23.9P Ch. 23.4 - Prob. 23.10P

Solution Summary: The author explains the citric acid cycle, which consists of enzyme catalyzed reactions occurring in mitochondria.

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