The bromination of compound followed by amination to synthesize glycine. Interpretation: The bromination of compound followed by amination to synthesize glycine is to be stated. Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine ( − NH 2 ) and carboxyl ( − COOH ) and these are prepared by reductive amination of α − ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

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Answer 1

Question

Chapter 24.5B, Problem 24.10P

(a)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize glycine.

Interpretation: The bromination of compound followed by amination to synthesize glycine is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

(b)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize leucine.

Interpretation: The bromination of compound followed by amination to synthesize leucine is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

(c)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize glutamic acid.

Interpretation: The bromination of compound followed by amination to synthesize glutamic acid is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

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Why do you wash the dichloromethane solution of your reductive amination product with sodium bicarbonate, rather than dilute aqueous HCl? a) Sodium bicarbonate is a good method of removing aldehydes from organic solvent.b) The amine product will be protonated by acid and remain in the aqueous layer as a salt.c) Sodium bicarbonate transfers the amine starting material into the aqueous layer.d) Sodium bicarbonate reacts with leftover NaBH(OAc)3 and removes it from the mixture.

Show how you would use bromination followed by amination to synthesize the followingamino acids. leucine

Show how you would use an acid chloride as an intermediate to synthesize(a) N-phenylbenzamide (PhCONHPh) from benzoic acid and aniline

Answer 2

Question

Chapter 24.5B, Problem 24.10P

(a)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize glycine.

Interpretation: The bromination of compound followed by amination to synthesize glycine is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

(b)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize leucine.

Interpretation: The bromination of compound followed by amination to synthesize leucine is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

(c)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize glutamic acid.

Interpretation: The bromination of compound followed by amination to synthesize glutamic acid is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

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Answer 3

Question

Chapter 24.5B, Problem 24.10P

(a)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize glycine.

Interpretation: The bromination of compound followed by amination to synthesize glycine is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

(b)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize leucine.

Interpretation: The bromination of compound followed by amination to synthesize leucine is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

(c)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize glutamic acid.

Interpretation: The bromination of compound followed by amination to synthesize glutamic acid is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

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Answer 4

Question

Chapter 24.5B, Problem 24.10P

(a)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize glycine.

Interpretation: The bromination of compound followed by amination to synthesize glycine is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

(b)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize leucine.

Interpretation: The bromination of compound followed by amination to synthesize leucine is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

(c)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize glutamic acid.

Interpretation: The bromination of compound followed by amination to synthesize glutamic acid is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

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Answer 5

Chapter 24.5B, Problem 24.10P

(a)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize glycine.

Interpretation: The bromination of compound followed by amination to synthesize glycine is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

(b)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize leucine.

Interpretation: The bromination of compound followed by amination to synthesize leucine is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

(c)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize glutamic acid.

Interpretation: The bromination of compound followed by amination to synthesize glutamic acid is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

Answer 6

Chapter 24.5B, Problem 24.10P

(a)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize glycine.

Interpretation: The bromination of compound followed by amination to synthesize glycine is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

Answer 7

Chapter 24.5B, Problem 24.10P

(a)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize glycine.

Interpretation: The bromination of compound followed by amination to synthesize glycine is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

Answer 8

(b)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize leucine.

Interpretation: The bromination of compound followed by amination to synthesize leucine is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

Answer 9

(b)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize leucine.

Interpretation: The bromination of compound followed by amination to synthesize leucine is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

Answer 10

(c)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize glutamic acid.

Interpretation: The bromination of compound followed by amination to synthesize glutamic acid is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

Answer 11

(c)

Interpretation Introduction

To determine: The bromination of compound followed by amination to synthesize glutamic acid.

Interpretation: The bromination of compound followed by amination to synthesize glutamic acid is to be stated.

Concept introduction: The process of an introduction of bromine atom into a compound is known as bromination. Amino acids are carbon containing compounds that possess two functional groups named as amine (−NH2) and carboxyl (−COOH) and these are prepared by reductive amination of α−ketoacids by using transaminase enzyme and bromination of carboxylic acid groups followed by amination. Reductive amination comprises transformation of carbonyl group of keto acids to an imine intermediate, which leads to the formation of an amine. Transaminase enzymes are specifically used for speed up the transamination reactions.

Answer 12

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Answer 13

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Answer 14

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Answer 15

Ch. 24.2A - Draw three-dimensional representations of the...Ch. 24.2A - Prob. 24.2P Ch. 24.2B - The herbicide glyphosate (Roundup) kills plants by...Ch. 24.4 - Draw the structure of the predominant form of a....Ch. 24.4 - Draw the resonance forms of a protonated guanidino...Ch. 24.4 - Although tryptophan contains a heterocyclic amine,...Ch. 24.4 - Prob. 24.7P Ch. 24.4 - Prob. 24.8P Ch. 24.5A - Show how the following amino acids might be formed...Ch. 24.5B - Prob. 24.10P

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