Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 25, Problem 23CONQ
Summary Introduction
To review:
Whether the alleles involved in genetic predisposition to cancer development are dominant or not. Also, show that the individuals who carry the dominant alleles do not get cancer during their lifetime.
Introduction:
Cancer is caused due to the mutations which occur in the genetic material of the cells. The mutated genes can be inherited or formed during the lifetime of the individuals. There is an increase in the chance of having cancer by the offspring if the parents are having oncogenic genes.
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Chapter 25 Solutions
Genetics: Analysis and Principles
Ch. 25.1 - Which of the following wouldnotbe consistent with...Ch. 25.1 - 2. Assuming complete penetrance, which type of...Ch. 25.1 - 3. Which of the following is not a common...Ch. 25.1 - Prob. 4COMQCh. 25.2 - Prob. 1COMQCh. 25.2 - Haplotype association studies are aimed at the...Ch. 25.3 - 1. Which of the following is not a method used in...Ch. 25.3 - 2. Which of the following prenatal genetic testing...Ch. 25.4 - Prob. 1COMQCh. 25.5 - 1. An oncogene is produced from a ________that has...
Ch. 25.5 - Which of the following is a type of genetic change...Ch. 25.5 - 3. Tumor-suppressor genes promote cancer...Ch. 25.5 - 4. Normal (nonmutant) tumor-suppressor genes often...Ch. 25.5 - Prob. 5COMQCh. 25.6 - Prob. 1COMQCh. 25 - 1. With regard to pedigree analysis, make a list...Ch. 25 - 2. Explain, at the molecular level, why human...Ch. 25 - 3. Many genetic disorders exhibit locus...Ch. 25 - Prob. 4CONQCh. 25 - Prob. 5CONQCh. 25 - Figure 25.1 illustrates albinism in two different...Ch. 25 - Prob. 7CONQCh. 25 - Prob. 8CONQCh. 25 - Ehler-Danlos syndrome is a rare disorder caused by...Ch. 25 - 10. Hurler syndrome is due to a mutation in a gene...Ch. 25 - Like Hurler syndrome, Fabry disease involves an...Ch. 25 - Achondroplasia is a rare form of dwarfism caused...Ch. 25 - Prob. 13CONQCh. 25 - 14. Marfan syndrome is due to a mutation in a...Ch. 25 - 15. Sandhoff disease is due to a mutation in a...Ch. 25 - Describe the two assumptions that underlie the...Ch. 25 - Prob. 17CONQCh. 25 - What is a prion? Explain how a prion relies on...Ch. 25 - 19. Some people have a genetic predisposition for...Ch. 25 - What is the difference between an oncogene and a...Ch. 25 - Prob. 21CONQCh. 25 - Prob. 22CONQCh. 25 - Prob. 23CONQCh. 25 - Prob. 24CONQCh. 25 - Prob. 25CONQCh. 25 - Prob. 26CONQCh. 25 - Prob. 27CONQCh. 25 - With regard to cancer cells, which of the...Ch. 25 - Prob. 29CONQCh. 25 - 1. Which of the following experimental...Ch. 25 - Prob. 2EQCh. 25 - 3. What is meant by the term genetic testing? How...Ch. 25 - Prob. 4EQCh. 25 - 5. Chapter 21 describes a method known as Western...Ch. 25 - 6. An experimental assay for the blood-clotting...Ch. 25 - 7. Discuss ways to distinguish whether a...Ch. 25 - 8. The codon change (Gly-12 to Val-12) in...Ch. 25 - Explain how DNA microarrays are used in molecular...Ch. 25 - Make a list of the benefits that may arise from...Ch. 25 - 2. Our government has finite funds to devote to...Ch. 25 - Prob. 3QSDC
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- Ultimately, cancer kills because it spreads and disturbs homeostasis. Consider, for example, a kidney cancer that metastasizes to the lungs and liver. What are some specific aspects of homeostasis that the spreading disease could affect?arrow_forwardHow does the multistep model of cancer explain the observation that sporadic cases of retinoblastoma usually appear in only one eye, whereas inherited forms of the cancer appear in both eyes?arrow_forwardSome cancers show increased incidence with age while others peak at younger ages. Whydo you suppose that some cancers have increased incidence with age while others peak inchildren?arrow_forward
- Describe two mechanisms by which genetic change causes cancer.arrow_forwardUnlike many other diseases, the vast majority of cancers in humans are not transmissible - meaning a person can’t ‘catch cancer’ from someone else. How does a person get cancer, then? Starting with a normal (non-cancerous) cell, describe a possible sequence of events that could eventually result in metastasized cancer, including the genes, structures or processes involved.arrow_forwardExplain how mutations in tumor-suppressor genes can be recessive at the level of the cell but cause dominantly inherited predispositions to cancer.arrow_forward
- Why is it only the risk for cancer that is inherited?arrow_forwardWhy is the tumor microenvironment important to cancer progression?arrow_forwardWhat is one type of cancer (in humans or other organisms) that you are familiar with or interested in? How often does this cancer occur? What are some genetic causes of this type of cancer?arrow_forward
- Heavy smokers or industrial workers exposed for a limited time to a chemical carcinogen that induces mutations in dna do not usually begin to develop cancers characteristic of their habit or occupation until 10, 20, or even more years after the exposure. suggest an explanation for this long delay.arrow_forwardDescribe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote cell-cycle arrest and apoptosis. Given that TP53 is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without the recessive gene?arrow_forwardExplain why it usually takes more than one mutation to cause cancerarrow_forward
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