Organic Chemistry
Organic Chemistry
6th Edition
ISBN: 9781936221349
Author: Marc Loudon, Jim Parise
Publisher: W. H. Freeman
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Chapter 25, Problem 25.20P
Interpretation Introduction

Interpretation:

The advantage of producing triphosphate as a leaving group rather than pyrophosphate is to be explained.

Concept Introduction:

The conversion of pyrophosphate to phosphate by inorganic pyrophosphatase makes many reactions favorable by coupling them to this irreversible reaction. If ADP were used as an adenosyl donor, then the product pyrophosphate would be hydrolyzed by SAM synthase. There will be no pyrophosphate left for hydrolysis by inorganic pyrophophatase.

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