Fundamentals of Biochemistry: Life at the Molecular Level
Fundamentals of Biochemistry: Life at the Molecular Level
5th Edition
ISBN: 9781118918401
Author: Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher: WILEY
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Chapter 25, Problem 26E
Summary Introduction

To explain: The reason behind the base excision repair, nucleotide excision repair, and mismatch repair require nucleases as well as DNA ligases.

Introduction: Mutations are the heritable change that makes changes in the DNA sequence of an organism. There are several mechanisms present in the cell to repair or prevent mutations. Such mechanism includes proofreading (self-work checking) and DNA repair systems. There are many repair systems such as base excision repair, nucleotide excision repair, and mismatch repair system. All of them require nucleases as well as DNA ligases for its proper functioning.

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