Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 25, Problem 2PDQ
CONCEPT QUESTION
Review the Chapter Concepts list on page 599. These all center around quantitative inheritance and the study and analysis of polygenic traits. Write a short essay that discusses the difference between the more traditional Mendelian and neo-Mendelian modes of inheritance (qualitative inheritance) and quantitative inheritance.
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Chapter 25 Solutions
Concepts of Genetics (12th Edition)
Ch. 25 - A homozygous plant with 20-cm-diameter flowers is...Ch. 25 - The following table shows measurements for fiber...Ch. 25 - The following cable gives the percentage of twin...Ch. 25 - At an interview with a genetic counselor, a couple...Ch. 25 - Prob. 2CSCh. 25 - At an interview with a genetic counselor, a couple...Ch. 25 - HOW DO WE KNOW? In this chapter, we focused on a...Ch. 25 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 25 - Define the following: (a) polygenic, (b) additive...Ch. 25 - A dark-red strain and a white strain of wheat are...
Ch. 25 - Height in humans depends on the additive action of...Ch. 25 - An inbred strain of plants has a mean height of 24...Ch. 25 - Erma and Harvey were a compatible barnyard pair,...Ch. 25 - In the following table, average differences of...Ch. 25 - What kind of heritability estimates (broad sense...Ch. 25 - List as many human traits as you can that are...Ch. 25 - Corn plants from a test plot are measured, and the...Ch. 25 - The following variances were calculated for two...Ch. 25 - The mean and variance of plant height of two...Ch. 25 - Prob. 14PDQCh. 25 - Prob. 15PDQCh. 25 - In an assessment of learning in Drosophila, flies...Ch. 25 - Prob. 17PDQCh. 25 - Prob. 18PDQCh. 25 - In a population of 100 inbred, genotypically...Ch. 25 - Many traits of economic or medical significance...Ch. 25 - A 3-inch plant was crossed with a 15-inch plant,...Ch. 25 - In a cross between a strain of large guinea pigs...Ch. 25 - Type A1B brachydactyly (short middle phalanges) is...Ch. 25 - In a series of crosses between two true-breeding...Ch. 25 - Students in a genetics laboratory began an...Ch. 25 - Prob. 26ESPCh. 25 - Canine hip dysplasia is a quantitative trait that...Ch. 25 - Floral traits in plants often play key roles in...Ch. 25 - In 1988, Horst Wilkens investigated blind...
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- Working with the definitions of penetrance and expressivity, analyze the following pedigree and assume that the father of the proband is homozygous for a rare trait. (Consider a rare trait here to be less than 1 in 30,000.) What pattern of inheritance other than autosomal recessive could explain this pedigree? In particular, explain the genotype and phenotype of the proband (arrow).arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?arrow_forward
- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?arrow_forwardCystic fibrosis is an autosomal disease that mainly affects the white population, and 1 in 20 whites are heterozygotes. Genetic testing can diagnose heterozygotes. Should a genetic screening program for cystic fibrosis be instituted? Should the federal government fund it? Should the program be voluntary or mandatory, and why?arrow_forwardAs it turned out, one of the tallest Potsdam Guards had an unquenchable attraction to short women. During his tenure as guard, he had numerous clandestine affairs. In each case, children resulted. Subsequently, some of the childrenwho had no way of knowing that they were relatedmarried and had children of their own. Assume that two pairs of genes determine height. The genotype of the 7-foot-tall Potsdam Guard was A9A9B9B9, and the genotype of all of his 5-foot clandestine lovers was AABB. An A9 or B9 allele in the offspring each adds 6 inches to the base height of 5 feet conferred by the AABB genotype. a. What were the genotypes and phenotypes of all the F1 children? b. Diagram the cross between the F1 offspring, and give all possible genotypes and phenotypes of the F2 progenyarrow_forward
- In a problem involving albinism (see Problem 4), which of Mendel’spostulates are demonstrated? Problem No. 4 Albinism in humans is inherited as a simple recessive trait.Determine the genotypes of the parents and offspring for thefollowing families. When two alternative genotypes are possible,list both.(a) Two parents without albinism have five children, four withoutalbinism and one with albinism.(b) A male without albinism and a female with albinism havesix children, all without albinism.arrow_forwardA couple who are about to get married learn from studying their family histories that, in both their families, theirunaffected grandparents had siblings with cystic fibrosis(a rare autosomal recessive disease).a. If the couple marries and has a child, what is theprobability that the child will have cystic fibrosis?b. If they have four children, what is the chance that thechildren will have the precise Mendelian ratio of 3:1 fornormal:cystic fibrosis?c. If their first child has cystic fibrosis, what is theprobability that their next three children will be normal?arrow_forwardTotal fingerprint ridge count exemplifies a polygenic inheritance pattern. Penrose (1969) and others have suggested that a minimum of seven gene loci contribute to TRC, but a four-locus model is hypothesized in the problems that follow. Thus, AABBCCDD represents the genotype for maximum ridge count and aabbccdd symbolizes the genotype for the minimum ridge count. Assume that each active allele adds 15 ridges to the TRC of the male and 12 to the TRC of the female and that having the genotype aabbccdd produces a baseline TRC of 70 for males and 50 for females. Predict the TRC for each of the following individuals: Genotype Male Female AABBCCDD AabbccDd AaBBCcDD aaBbCCDd A. Write the genotypes of parents who are heterozygous for all four genes. B. Write the genotype of their child who has the maximum number of active alleles possible. C. What are the TRCs for the parents? D. What is the TRC of the child from B (assume male)?…arrow_forward
- Total fingerprint ridge count exemplifies a polygenic inheritance pattern. Penrose (1969) and others have suggested that a minimum of seven gene loci contribute to TRC, but a four-locus model is hypothesized in the problems that follow. Thus, AABBCCDD represents the genotype for maximum ridge count and aabbccdd symbolizes the genotype for the minimum ridge count. Assume that each active allele adds 15 ridges to the TRC of the male and 12 to the TRC of the female and that having the genotype aabbccdd produces a baseline TRC of 70 for males and 50 for females. Predict the TRC for each of the following individuals: Genotype Male Female AABBCCDD AabbccDd AaBBCcDD aaBbCCDdarrow_forwardPlease define the following terms: Gene Allele Dominant Recessive Homozygous Heterozygousarrow_forwardWhat findings led geneticists to postulate the multiple- factor hypothesis that invoked the idea of additive alleles to explain inheritance patterns?arrow_forward
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