Chapter 26, Problem 1AQ

Summary Introduction

To identify:

Identify the significances of a genetic mutation that eliminates a pattern recognition receptor (PRR) by means of predicting the outcome for the host. Do this for at least one soluble PRR and one membrane-bound PRR.

Introduction:

The first line of defense mechanism is carried out by phagocytes like neutrophils and macrophages when the pathogens entering the human system. Phagocytes interact rapidly and efficiently with pathogens or foreign particles as they have evolved specialized molecules are known as pattern recognition receptors (PRRs), which directly interact with pathogen-associated molecular patterns (PAMPs).