EBK BROCK BIOLOGY OF MICROORGANISMS
15th Edition
ISBN: 8220103633352
Author: Stahl
Publisher: PEARSON
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Chapter 27.7, Problem 1MQ
Summary Introduction
Major histocompatibility complex is the group of genes that encode for proteins that are crucial for antigen presentation. This MHC gene is located on chromosome 6 and code for MHC protein. MHC proteins are classified into two classes MHC I and MHC II, these cell surface proteins recognize and bind with antigens from pathogens and present them to immune cells. MHCs regulate adaptive immune response.
The MHC proteins are called as human leukocyte antigens (HLAs) in case of humans. These proteins are responsible for antigen presentation to the T cell receptors. T cell receptors are formed by combination of three different complementarity determining regions CDR (1, 2 and 3).
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Chapter 27 Solutions
EBK BROCK BIOLOGY OF MICROORGANISMS
Ch. 27.1 - Prob. 1MQCh. 27.1 - Prob. 2MQCh. 27.1 - Distinguish between clonal deletion and clonal...Ch. 27.1 - QWhy is it necessary that all three defining...Ch. 27.2 - Identify the intrinsic and extrinsic properties of...Ch. 27.2 - Describe an epitope recognized by an antibody, and...Ch. 27.2 - Give an example for each: natural and artificial...Ch. 27.2 - QWhat properties are required for a vaccine to...Ch. 27.3 - Summarize antibody production starting with...Ch. 27.3 - Differentiate among antibody classes using...
Ch. 27.3 - Prob. 3MQCh. 27.3 - QDescribe the structural and functional...Ch. 27.4 - Draw a complete Ig molecule and identify...Ch. 27.4 - Describe antigen binding to the CDR1, 2, and 3...Ch. 27.4 - Describe the recombination events that produce a...Ch. 27.4 - QWhich Ig chains are used to construct a complete...Ch. 27.5 - Identify the cells that display MHC class I and...Ch. 27.5 - Compare the MHC I and MHC II protein structures...Ch. 27.5 - Define the sequence of events for processing and...Ch. 27.5 - QDescribe the basic structure of class I and class...Ch. 27.6 - Define polymorphism and polygeny as they apply to...Ch. 27.6 - How does a single MHC protein present many...Ch. 27.6 - QPolymorphism implies that each different MHC...Ch. 27.7 - Prob. 1MQCh. 27.7 - Identify diversity-generating mechanisms unique to...Ch. 27.7 - Describe and compare the structural features of Ig...Ch. 27.7 - QWhat diversity-generating mechanisms function to...Ch. 27.8 - Describe the mechanism used by Tc cells to...Ch. 27.8 - Describe the effector system (the cell-killing...Ch. 27.8 - Compare and contrast the roles and activities of...Ch. 27.8 - QWhat mechanism do Tc cells use to identify and...Ch. 27.9 - Discriminate between immediate hypersensitivity...Ch. 27.9 - Provide examples and mechanisms for an...Ch. 27.9 - QHow do immediate and delayed-type...Ch. 27.10 - Describe the binding site for superantigens on T...Ch. 27.10 - Compare and contrast the immunodeficiency observed...Ch. 27.10 - Prob. 3MQCh. 27.10 - Prob. 1CRCh. 27 - Antibodies of the IgA class are probably more...Ch. 27 - Prob. 2AQCh. 27 - Polymorphism implies that each different MHC...Ch. 27 - What problems would arise if a person had a...
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Similar questions
- Describe the binding site for superantigens on T cells andAPCs. How does this relate to the activation of a much largerpopulation of T cells than normal upon exposure tosuperantigens?arrow_forwardList the two important features of clonal selection.arrow_forwardWhat type of genetic disease is T-cell signaling deficiency? (Dominant/ Recessive, Autosomal/Sex-Linked)?arrow_forward
- What is the relationship between self-tolerance and clonal deletion?arrow_forwardDefine suppressor T cellarrow_forwardWhich of the following is part of the T-cell clonal deletion process? a) T-cells are eliminated if they bind to B-cells b) Lymphocytes that bind to MHC undergo apoptosis c) T-cells that bind to the same antigen as B-cells are eliminated d) Lymphocytes that react to autoantigens undearrow_forward
- Explain the mechanisms by which antibody diversity and T-cell receptor diversity are achieved.arrow_forwardList step-by-step the two ways CD8 T cells can trigger apoptosis.arrow_forwardHow is the newly emerging repertoire of T cells, with their diverse pre-TCRs, further differentiated so that a productive interaction with self-MHC–peptide complexes can occur?arrow_forward
- What is the difference between predominant and subordinate monoclonal genes? Note the different genetic ratios and name examples of both.arrow_forwardWhat are the functions of CD4 and CD8 proteins on the surface of T cells?arrow_forwardProvide one common feature and two differences between B-cell receptors and PRRs.arrow_forward
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