EBK BROCK BIOLOGY OF MICROORGANISMS
15th Edition
ISBN: 8220103633352
Author: Stahl
Publisher: PEARSON
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Textbook Question
Chapter 27.5, Problem 2MQ
Compare the MHC I and MHC II protein structures and peptide-binding sites. How do they differ? How are they similar?
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Chapter 27 Solutions
EBK BROCK BIOLOGY OF MICROORGANISMS
Ch. 27.1 - Prob. 1MQCh. 27.1 - Prob. 2MQCh. 27.1 - Distinguish between clonal deletion and clonal...Ch. 27.1 - QWhy is it necessary that all three defining...Ch. 27.2 - Identify the intrinsic and extrinsic properties of...Ch. 27.2 - Describe an epitope recognized by an antibody, and...Ch. 27.2 - Give an example for each: natural and artificial...Ch. 27.2 - QWhat properties are required for a vaccine to...Ch. 27.3 - Summarize antibody production starting with...Ch. 27.3 - Differentiate among antibody classes using...
Ch. 27.3 - Prob. 3MQCh. 27.3 - QDescribe the structural and functional...Ch. 27.4 - Draw a complete Ig molecule and identify...Ch. 27.4 - Describe antigen binding to the CDR1, 2, and 3...Ch. 27.4 - Describe the recombination events that produce a...Ch. 27.4 - QWhich Ig chains are used to construct a complete...Ch. 27.5 - Identify the cells that display MHC class I and...Ch. 27.5 - Compare the MHC I and MHC II protein structures...Ch. 27.5 - Define the sequence of events for processing and...Ch. 27.5 - QDescribe the basic structure of class I and class...Ch. 27.6 - Define polymorphism and polygeny as they apply to...Ch. 27.6 - How does a single MHC protein present many...Ch. 27.6 - QPolymorphism implies that each different MHC...Ch. 27.7 - Prob. 1MQCh. 27.7 - Identify diversity-generating mechanisms unique to...Ch. 27.7 - Describe and compare the structural features of Ig...Ch. 27.7 - QWhat diversity-generating mechanisms function to...Ch. 27.8 - Describe the mechanism used by Tc cells to...Ch. 27.8 - Describe the effector system (the cell-killing...Ch. 27.8 - Compare and contrast the roles and activities of...Ch. 27.8 - QWhat mechanism do Tc cells use to identify and...Ch. 27.9 - Discriminate between immediate hypersensitivity...Ch. 27.9 - Provide examples and mechanisms for an...Ch. 27.9 - QHow do immediate and delayed-type...Ch. 27.10 - Describe the binding site for superantigens on T...Ch. 27.10 - Compare and contrast the immunodeficiency observed...Ch. 27.10 - Prob. 3MQCh. 27.10 - Prob. 1CRCh. 27 - Antibodies of the IgA class are probably more...Ch. 27 - Prob. 2AQCh. 27 - Polymorphism implies that each different MHC...Ch. 27 - What problems would arise if a person had a...
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- What types of cells display MHC class I and class IIantigen complexes, and what happens as a result?arrow_forwardList the steps of MHC class II peptide formation and assembly.arrow_forwardWhich of the following best describes the sequence variation within class | MHC molecules? A) Concentrated in the peptide-binding groove B) Concentrated near the transmembrane domain C) Concentrated within the cytoplasmic domain D) Concentrated within microglobulin E) Distributed fairly evenly throughout the moleculearrow_forward
- What are chimeric antigen receptors (CARs) ?arrow_forwardThe virus shown in the diagram below is only able to infect and replicate in epithelial cells. In order for the cross-presenting dendritic cell to display viral peptides, rather than self peptides on its surface MHC class I proteins, which of the following procedures could be utilized, starting with the components shown in the figure below? Mix epithelial cells with heat-killed virus, wait 24 hrs, wash away any virus particles outside the epithelial cells, then add epithelial cells to dendritic cells. Mix epithelial cells with viral peptides, wait 24 hrs, wash away any viral peptides not bound to the epithelial cells, then add epithelial cells to dendritic cells. Mix epithelial cells with live virus particles, wait 24 hrs, wash away any virus particles outside the epithelial cells, then add epithelial cells to dendritic cells. Mix dendritic cells with viral nucleic acids and epithelial cells for 24 hrs. MIx epithelial cells will viral nucleic acids, wait 24 hrs, wash away any viral…arrow_forwardList the steps of MHC class I peptide formation and assembly.arrow_forward
- The ends of each heavy chain and light chain in an immunoglobulin make up the antigen-binding sites. The end of one of these chains is shown here. Biochemists tend to classify protein structures into four groups: mostly alpha, mostly beta, mixed alpha and beta, or neither alpha nor beta. Based on the model shown here, how would you classify this part of the immunoglobulin protein? The loopy polypeptide segments at the very top of the structure shown are the segments that actually contact the antigen. Would you expect these binding segments to be rigid or flexible?arrow_forwardHow does a single MHC protein present many differentpeptides to T cells?arrow_forwardHuman immune system a) Pathogen-associated molecular patterns are conserved molecular structures produced by microorganisms, but not by host cells. b) A virus-infected host cell that displays a viral antigen via MHC class I molecules may become a target of cytotoxic T cells. c) Secreted MHC Class I proteins present in blood plasma can function as opsonins. d) Both (a) and (b) are correct and (c) is incorrect e) Statements (a), (b) and (c) are all correctarrow_forward
- Which of the following cells demonstrate MHC II molecules on their surface membrane? 1. B lymphocyte 2. macrophage 3. erythrocyte 4. neuron 5. smooth muscle cell Choose from the following: (A) 1 and 2 (B) 1, 2 and 3 (C) 1, 2, 4, and 5 (D) 1, 2, 3, 4, and 5arrow_forwardDuring MHC class I synthesis and folding in the endoplasmic reticulum (ER), a process of peptide editing takes place as the newly synthesized MHC class I protein is held in a 'peptide-receptive state' by binding to the calreticulin:ERp57:tapasin complex. Peptide editing ensures that the MHC class I molecules that reach the cell surface have stable, high-affinity binding for their peptide cargo. Peptide editing is important to the immune response because it maintains high levels of surface MHC class I expression. ensures that MHC class I molecules are not degraded in the ER. prevents surface MHC class I molecules from undergoing peptide exchange at the cell surface. retains the nascent MHC class I molecule in a peptide-receptive state. 000arrow_forwardOn which types of cells are the two classes of major histocompatibility complex (MHC) proteins located and what type of antigen do they display? MHC I proteins are found on the surface of antigen-presenting cells and display exogenous antigens, while MHC II proteins are found on the surface of most cells, and display endogenous antigens. MHC I proteins are found inside most cells, and display exogenous antigens, while MHC II proteins are found on the surface of antigen-presenting cells and display endogenous antigens. MHC I proteins are found inside all cells and display exogenous antigens, while MHC II proteins are found inside antigen-presenting cells and display endogenous antigens. MHC I proteins are found on the surface of most cells and display endogenous antigens, while MHC II proteins are only found on antigen-presenting cells and display exogenous antigens.arrow_forward
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