A dominantly inherited genetic disease is identified over several generations of a large family. However, about half the families have dominant disease with complete penetrance , whereby if a parent is affected there is a 50% probability that any one offspring will be affected. Similarly, about half the families have dominant disease with reduced penetrance , whereby if a parent is affected there is a 25% probability that any one offspring will be affected. Suppose in a particular family one parent and two of the two offspring are affected. What is the probability that the mode of transmission for this particular family is dominant with complete penetrance? Is this a prior probability or a posterior probability?
A dominantly inherited genetic disease is identified over several generations of a large family. However, about half the families have dominant disease with complete penetrance , whereby if a parent is affected there is a 50% probability that any one offspring will be affected. Similarly, about half the families have dominant disease with reduced penetrance , whereby if a parent is affected there is a 25% probability that any one offspring will be affected. Suppose in a particular family one parent and two of the two offspring are affected. What is the probability that the mode of transmission for this particular family is dominant with complete penetrance? Is this a prior probability or a posterior probability?
Solution Summary: The author explains the probability that the mode of transmission for this particular family is dominant with complete penetrance.
A dominantly inherited genetic disease is identified over several generations of a large family. However, about half the families have dominant disease with complete penetrance, whereby if a parent is affected there is a 50% probability that any one offspring will be affected. Similarly, about half the families have dominant disease with reduced penetrance, whereby if a parent is affected there is a 25% probability that any one offspring will be affected.
Suppose in a particular family one parent and two of the two offspring are affected.
What is the probability that the mode of transmission for this particular family is dominant with complete penetrance? Is this a prior probability or a posterior probability?
Definition Definition Measure of central tendency that is the value that occurs most frequently in a data set. A data set may have more than one mode if multiple categories repeat an equal number of times. For example, in a data set with five item—3, 5, 5, 29, 473—the mode is 5 because it occurs twice and no other value occurs more than once. On a histogram or bar chart, the element with the highest bar represents the mode. Therefore, the mode is sometimes considered the most popular option. The mode is useful for nominal or categorical data (e.g., the most common color car that users purchase), but it is problematic for continuous data because it is more likely not to have any value that is more frequent than the other.
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Discrete Distributions: Binomial, Poisson and Hypergeometric | Statistics for Data Science; Author: Dr. Bharatendra Rai;https://www.youtube.com/watch?v=lHhyy4JMigg;License: Standard Youtube License