Concept explainers
To review:
The diet group having highest LDL (low-density lipoprotein) to HDL (high-density lipoprotein) ratio. The results of the study are shown in the table given below:
Effect of Diet on Lipoprotein levels (mg/dL or milligram per deciliter) | ||||
cis Fatty acids | Trans Fatty acids | Saturated Fats | Optimal level | |
LDL | 103 | 117 | 121 | <100 |
HDL | 55 | 48 | 55 | >40 |
LDL-to-HDL ratio | 1.87 | 2.43 | 2.2 | <2 |
Introduction:
Lipoproteins are made up of proteins and lipids. These molecules help in the transportation of lipids (mainly cholesterol) in the blood or extracellular fluid. The phospholipids are present on the exterior while other lipids lie in the interior. Phospholipids are oriented in such a way that the hydrophilic part is on the outer side while the hydrophobic part is on the inner side.
On basis of density, lipoproteins are classified as Ultra Low-Density Lipoproteins (ULDL), Intermediate Density Lipoproteins (IDL), Very Low-Density Lipoproteins (VLDL), LDL, and HDL. The LDL and HDL are of clinical importance and are classified as bad cholesterol and good cholesterol, respectively.
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Biology: The Dynamic Science (MindTap Course List)
- Effects of Dietary Fats on Lipoprotein Levels Cholesterol that is made by the liver or that enters the body from food does not dissolve in blood, so it is carried through the bloodstream by lipoproteins. Low-density lipoprotein (LDL) carries cholesterol to body tissues such as artery walls, where it can form deposits associated with cardiovascular disease. Thus, LDL is often called bad cholesterol. Highdensity lipoprotein (HDL) carries cholesterol away from tissues to the liver for disposal, so HDL is often called good cholesterol. In 1990, Ronald Mensink and Martijn Katan published a study that tested the effects of different dietary fats on blood lipoprotein levels. Their results are shown in Figure 2.23. In which group was the level of LDL (bad cholesterol) highest?arrow_forwardEffects of Dietary Fats on Lipoprotein Levels Cholesterol that is made by the liver or that enters the body from food does not dissolve in blood, so it is carried through the bloodstream by lipoproteins. Low-density lipoprotein (LDL) carries cholesterol to body tissues such as artery walls, where it can form deposits associated with cardiovascular disease. Thus, LDL is often called bad cholesterol. Highdensity lipoprotein (HDL) carries cholesterol away from tissues to the liver for disposal, so HDL is often called good cholesterol. In 1990, Ronald Mensink and Martijn Katan published a study that tested the effects of different dietary fats on blood lipoprotein levels. Their results are shown in Figure 2.23. Figure 2.23 Effect of diet on lipoprotein levels. Researchers placed 59 men and women on a diet in which 10 percent of their daily energy intake consisted of cis fatty acids, trans fatty acids, or saturated fats. Blood LDL and HDL levels were measured after three weeks on the diet; averaged results are shown in mg/dL (milligrams per deciliter of blood). All subjects were tested on each of the diets. The ratio of LDL to HDL is also shown. Source, Mensink RP, Katan MB, Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects. NEJM 323(7):43945. An elevated risk of heart disease has been correlated with increasing LDL-to-HDL ratios. Rank the three diets according to their predicted effect on cardiovascular health.arrow_forwardEffects of Dietary Fats on Lipoprotein Levels Cholesterol that is made by the liver or that enters the body from food does not dissolve in blood, so it is carried through the bloodstream by lipoproteins. Low-density lipoprotein (LDL) carries cholesterol to body tissues such as artery walls, where it can form deposits associated with cardiovascular disease. Thus, LDL is often called bad cholesterol. Highdensity lipoprotein (HDL) carries cholesterol away from tissues to the liver for disposal, so HDL is often called good cholesterol. In 1990, Ronald Mensink and Martijn Katan published a study that tested the effects of different dietary fats on blood lipoprotein levels. Their results are shown in Figure 2.23. In which group was the level of HDL (good cholesterol) lowest?arrow_forward
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