Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 30, Problem 7P
Interpretation Introduction
Interpretation:
The effect of a mutation that avoids the σ subunit from separating from the RNA polymerase core should be determined.
Concept introduction:
Non-competitive inhibition can be defined as a type of enzyme inhibition. In this inhibition, usually, the inhibitor diminishes the enzyme activity. The inhibitor gets fixed like the normal substrate does to the enzyme. It occurs even if it has been previously bound or not to the substrate. Unlike competitive inhibition, non-competitive inhibition cannot be overcome with the additional substrate.
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Remember remove the introns! All introns start with GT and end with AG.
RNA polymerase from E. coli (core enzyme alone) has all of the following properties except:
a)requires all four ribonucleoside triphosphates and a DNA template.
b)can extend an RNA chain and initiate a new chain.
c)recognizes specific start signals in DNA.
d)produces an RNA polymer that begins with a 5'-triphosphate.
e)is required for the synthesis of mRNA, rRNA, and tRNA in E. coli.
Question:-
Describe the function of each of the following Shortly.
a. Amino-acyl tRNA synthetase
b. E coll release factors 1 and 2 (RF1 and RF2)
c. 5' methyl-guanosine cap
d. Ribosomal P site
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