The reason for the loss of DNA in mature B and T cells, focusing primarily on the similarities between cellular and organismal generations. Introduction: T cells and the B cells are the cells that provide cellular immunity to the body. These cells posses the receptors or the antibodies that recognize a foreign antigen. This process in turn elicits the immune response of the body.

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Chapter 35, Problem 10TYU

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The reason for the loss of DNA in mature B and T cells, focusing primarily on the similarities between cellular and organismal generations.

Introduction:

T cells and the B cells are the cells that provide cellular immunity to the body. These cells posses the receptors or the antibodies that recognize a foreign antigen. This process in turn elicits the immune response of the body.

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The T-cell receptor gene segments are arranged in a similar pattern to immunoglobulin gene segments and are rearranged by the same enzymes. While B cells and T cells differ markedly in their functions during an immune response, the two lymphocyte subsets share the enzymatic machinery and overall scheme for generating antigen receptor diversity. This is because: B cells and T cells recognize the same form of antigen expressed by an infecting pathogen. Animals with B cells developed first, and later evolving species then developed T cells. B cells and T cells both need enormous antigen receptor diversity to provide protection against the diversity of pathogens. Antibody and T-cell receptor gene segments are both flanked by similar recombination signal sequences. B cells and T cells both secrete their antigen receptor proteins after they are activated by antigen-binding.