BIOCHEMISTRY (LOOSELEAF)-W/ACCESS
9th Edition
ISBN: 9781319425784
Author: BERG
Publisher: Macmillan Higher Education
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Chapter 36, Problem 13P
Interpretation Introduction
Interpretation:
The additional structure present in the KIF1A other than motor domain should be determined.
Concept introduction:
KIF1A is a motor protein. This protein is special as it moves only toward the positive end of the microtubules as a monomer. It has a motor domain which helps in its movement.
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Chapter 2: CARBOHYDRATES
SELF-ASSESSMENT EXERCISES
I. Essay questions
1. Define and classify carbohydrates with suitable examples. Add a note on the functions of
carbohydrates.
2. Describe the structure and functions of mucopolysaccharides.
3. Give an account of the structural configuration of monosaccharides, with special reference to
glucose.
4. Discuss the structure and functions of 3 biochemically important disaccharides.
5. Define polysaccharides and describe the structure of 3 homopolysaccharides.
III. Fill…
CENTRAL DOGMA & STRUCTURE-FUNCTION RELATIONSHIPS IN PROTEINS
You are a bacteriologist studying a pathogenic protein (the "BAD" protein) that contributes to diseases
caused by Staphylococcus aureus. BAD functions as an aß heterodimer, and the a subunit (25kD)
and ß subunit (75KD) are held together by an electrostatic interaction between K in the a subunit and
D in the B subunit.
You are trying to dissociate the BAD subunits to prevent pathogenesis in the bacteria. Which
mutation would you make to prevent the BAD subunits from forming a dimer? Assume neutral pH.
(A) introduce AAA → AGA point mutation in the a subunit gene
(B) introduce GAC → GAG point mutation in the ß subunit gene
(C) introduce GAT → CGT point mutation in the ß subunit gene
(D) introduce two point mutations: AAG → GTG in the a subunit gene & GAC → CTC in the B subunit
gene
(E) introduce two point mutations: AAA → TGC in the a subunit gene & GAT → TGT in the B subunit
gene
second base in codon
A
TGT Cys
TGC Cys
TTT Phe…
7 Protein structure.Circle one of the three amino acid sequences that is most likely to
form a stable a-helix?
RASKTARQ
DASKTAEQ
KPGKPAGQ
In one sentence (that can be accompanied by a small picture) explain why?
Chapter 36 Solutions
BIOCHEMISTRY (LOOSELEAF)-W/ACCESS
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