Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 4, Problem 42P
Consider the following pedigrees from human families containing a male with Klinefelter syndrome (a set of abnormalities seen in XXY individuals; indicated with shaded boxes). In each, A and B refer to codominant alleles of the X-linked G6PD gene. The
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Explain why it is possible for the proband in the following pedigree to have children of blood types A, B, and AB. Considering epistatic genes, what are the possible genotypes of II-2?
The following pedigree describes the inheritance of Lesch-Nyhan syndrome, an x-linked recessive disease. Affected individuals are shaded. what is the probability, that the indicated child (IV.1) will be affected by Lesch-Nyhan syndrome?
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In the pedigree below, male II-1 has Klinefelter syndrome, which is the
result of an XXY karyotype.
On the X chromosome, a gene called G6PD has two codominant
alleles, G6PDA and G6PDB. In this pedigree, A, B, and AB refer to the
phenotypes associated with the alleles of this gene. (Note: In this family,
no individuals have the AB version of the phenotype.)
A
A
B
Based on the information in the pedigree, when could nondisjunction
have occurred? Select all correct answers.
In Il-1's father, during meiosis I
In II-1's mother, during meiosis I
In II-1's mother, during meiosis II
In Il-1's father, during meiosis II
Chapter 4 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 4 - Choose the best matching phrase in the right...Ch. 4 - Humans have 46 chromosomes in each somatic cell....Ch. 4 - The figure that follows shows the metaphase...Ch. 4 - XX males who are sex-reversed because they have a...Ch. 4 - Researchers discovered recently that the sole...Ch. 4 - One oak tree cell with 14 chromosomes undergoes...Ch. 4 - Indicate which of the cells numbered iv matches...Ch. 4 - a. What are the four major stages of the cell...Ch. 4 - Answer the questions that follow for each stage of...Ch. 4 - Does any reason exist that would prevent mitosis...
Ch. 4 - One oak tree cell with 14 chromosomes undergoes...Ch. 4 - Which types of cell division mitosis, meiosis I,...Ch. 4 - Complete the following statements using as many of...Ch. 4 - The five cells shown in figure a e on the next...Ch. 4 - One of the first microscopic observations of...Ch. 4 - A person is simultaneously heterozygous for two...Ch. 4 - Assuming i that the two chromosomes in homologous...Ch. 4 - In the moss Polytrichum commune, the haploid...Ch. 4 - Does any reason exist that would prevent meiosis...Ch. 4 - Sister chromatids are held together through...Ch. 4 - The pseudoautosomal regions PARs of the X and Y...Ch. 4 - Somatic cells of chimpanzees contain 48...Ch. 4 - In humans: a. How many sperm develop from 100...Ch. 4 - Women sometimes develop benign tumors called...Ch. 4 - In a certain strain of turkeys, unfertilized eggs...Ch. 4 - Imagine you have two pure-breeding lines of...Ch. 4 - A system of sex determination known as...Ch. 4 - In Drosophila, the autosomal recessive brown eye...Ch. 4 - Barred feather pattern is a Z-linked dominant...Ch. 4 - When Calvin Bridges observed a large number of...Ch. 4 - In a vial of Drosophila, a research student...Ch. 4 - In 1919, Calvin Bridges began studying an X-linked...Ch. 4 - In Drosophila, a cross was made between a...Ch. 4 - As we learned in this chapter, the white mutation...Ch. 4 - The following is a pedigree of a family in which a...Ch. 4 - Each of the four pedigrees that follow represents...Ch. 4 - The pedigree that follows indicates the occurrence...Ch. 4 - Duchenne muscular dystrophy DMD is caused by a...Ch. 4 - The X-linked gene responsible for DMD encodes a...Ch. 4 - Males have hemophilia when they are hemizygous for...Ch. 4 - Consider the following pedigrees from human...Ch. 4 - Several different antigens can be detected in...Ch. 4 - The ancestry of a white female tiger bred in a...Ch. 4 - The pedigree at the bottom of the page shows the...Ch. 4 - In 1995, doctors reported a Chinese family in...Ch. 4 - In cats, the dominant 0 allele of the X-linked...Ch. 4 - In marsupials like the opposum or kangaroo, X...Ch. 4 - The pedigree diagram below shows a family in which...
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- Two fruit flies (Drosophila melanogaster) were crossed. The cross was between a homozygous red-eyed, wingless female and a white-eyed male heterozygous for wings. Recall that red eyes (R) is dominant over white eyes (r) and is inherited on the X chromosome (sex-linked) and as such, eye colour alleles should be written as superscript. In addition, the autosomal trait wings (W) is dominant over wingless (w). 1. List the female genotype 2. List the male genotype 3. Construct a Punnett Square for this dihybrid cross on a piece of paper, to determine what the offspring of such a cross would be with respect to sex, eye colour & wings. 4. Using the information from your Punnett Square answer the following: a. What genotypes did you get (list all genotype combinations; if you have more than one of the same kind, you do NOT have to re-list it.) b. What are the phenotypic ratios of the offspring with respect to sex, eye colour and wings?arrow_forwardThe following pedigree illustrates the inheritance of Nance–Horan syndrome, a rare genetic condition in which affected people have cataracts and abnormally shaped teeth.arrow_forwardCongenital hypertrichosis (CH) is a very rare X-linked dominant inherited condition. CH is characterized by the growth of dark hair over the body. CH is so rare, only 50 cases have been identified since the Middle Ages. The incidence of this condition is considerably higher in a small Mexican village (from which the partial pedigree below is derived) than the rest of the human population. I II III Use the following information to answer the two questions. IV D II-4 8 9 IV-6 0=10~ 11 1. Using appropriate nomenclature, identify the genotypes for the following 2 individuals: 12 13 your response must include an appropriate legend/key to identify allele symbols. 2. Show how a Punnett square (using the allele symbols from the previous question) is used to determine the probability in percent of individuals III-11 and III-12 next offspring has CH?arrow_forward
- This pedigree consist of cystic fibrosis that is an inherited disease caused by f a recessive allele. Find the genotypes of X and M? Given: O normal female □ normal male ◍ cystic fibrosis female ▨ cystic fibrosis male A) M= Ff X=Ff B) M=Ff X=ff C) M=ff X=ff D) M=ff X=FFarrow_forwardShown above is a family pedigree tree in which family members afflictedwith the disease Haemophilia are shown with filled-in squares (male) or circles (females). A couple is trying to determine the likelihood of passingon the disease to their future children (represented by the ? symbolabove) because the hemophilia runs in the woman’s family. Turner syndrome is a disease in which an individual is bornwith only a single X chromosome. Suppose the woman in thecouple is a carrier for hemophilia and has a child with Turnersyndrome. Would this child have the disease?arrow_forwardThe following is a linkage map of chromosome 5 for three genes in tomato: (see image) The cross between the triple heterozygote (Lf J W/ lf j w) and a triple homozygous recessive produced 500 progeny. Assume that there is no interference in the Lf-W region. Give the expected number of individuals for each of the following progeny types and show complete solutions.a. with crossover in the Lf-J and J-W regionsb. with crossover in the Lf-J regionc. with crossover in the J-W regiond. without crossover in the Lf-W regionarrow_forward
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