Pearson eText Genetic Analysis: An Integrated Approach -- Instant Access (Pearson+)
3rd Edition
ISBN: 9780135564172
Author: Mark Sanders, John Bowman
Publisher: PEARSON+
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Textbook Question
Chapter 5, Problem 28P
Neurofibromatosis
a. Determine the alleles for the
b. Based on the phase of alleles on chromosomes in generation
c. What is the estimated recombination frequency between the
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Examine the two pedigrees shown in Figure Q7–3.One results from deletion of a maternally imprinted auto-somal gene. The other pedigree results from deletion of apaternally imprinted autosomal gene. In both pedigrees,affected individuals (red symbols) are heterozygous forthe deletion. These individuals are affected because onecopy of the chromosome carries an imprinted, inactivegene, while the other carries a deletion of the gene. Dottedyellow symbols indicate individuals that carry the deletedlocus, but do not display the mutant phenotype. Whichpedigree is based on paternal imprinting and which onmaternal imprinting? Explain your answer.
The DNA of every individual in the pedigree shown
below has been sequenced at the causative locus.
All the non-shaded individuals are wild type apart
from III.1. III.1 has been proven to have the
causative mutation for this autosomal dominant
condition, but they exhibit no symptoms. Based on
this small pedigree, what is the level of penetrance
for the condition? Please give your answer as a
WHOLE percentage, give the number only, no
percentage symbol.
Answer: The level of penetrance for the
condition shown in the pedigree below is Blank 1
percent.
1:1
1:2
Il:1
I1:2
I1:3
Il:4
I1:5
I1:6
II:1 I:2 III:3
III:4
III:3 III:6 III:7
III:8
III:9
III:10 III:11 III12 II:13 III:14
IV:1 | IV:2 IV:3 IV:4 IV:5 IV:6 IV:7 IV:8 IV:9 IV:10 IV:11 IV:12 IV:13 IV:14 IV:15 IV:16 IV:17
IV:18 IV:19
V:1 V:2 V:3 V:4 V:5
V:6
V:7
V:8 V:9
V:10
V:11 V:12
Given the following genetic map, predict the chance an offspring would inherit the exact same haplotypes that the parents had.
Assume interference in this area of the chromosome is 5%. Please report your value as a percent (%).
A
|-- 3 mu -- |-- 12 mu -- |
Parent 1 Haplotypes: A1 B6 C14/A5 B1 C3
Parent 2 Haplotypes: A8 B3 C2 / A7 B2 C5
Chapter 5 Solutions
Pearson eText Genetic Analysis: An Integrated Approach -- Instant Access (Pearson+)
Ch. 5 - For parts a, b, and c, draw a diagram illustrating...Ch. 5 - 5.2 In a diploid species of plant, the genes for...Ch. 5 - A pure-breeding tall plant producing oval fruit as...Ch. 5 - 5.4 Genes E and H are syntenic in an experimental...Ch. 5 - In tomato plants, purple leaf color is controlled...Ch. 5 - 5.6 In Drosophila, the map positions of genes are...Ch. 5 - 5.7 Genes A, B, and C are linked on a chromosome...Ch. 5 - Gene G recombines with gene T at a frequency of...Ch. 5 - Genes A, B, C, D, and E are linked on a...Ch. 5 - Syntenic genes can assort independently. Explain...
Ch. 5 - 5.11 The recombination frequency between linked...Ch. 5 - On the DrosophilaX chromosome, the dominant allele...Ch. 5 - Researchers cross a corn plant that is pure -...Ch. 5 - 5.14 syndrome is an autosomal disorder affecting...Ch. 5 - 5.15 Three dominant traits of corn seedlings,...Ch. 5 - 5.16 In a diploid plant species, an with the...Ch. 5 - Prob. 17PCh. 5 - The Rh blood group in humans is determined by a...Ch. 5 - 5.19 Genetic linkage mapping for a large number of...Ch. 5 - 5.20 with the genotype form tetrads in the...Ch. 5 -
Gene and gene are genetically linked. Answer...Ch. 5 -
T. H. Morgan’s data on eye color and wing form,...Ch. 5 - Prob. 23PCh. 5 -
The boss in your laboratory has just heard of a...Ch. 5 - In rabbits, chocolate-colored fur (w+) is dominant...Ch. 5 - Prob. 26PCh. 5 - 5.27 In tomatoes, the allele for tall plant height...Ch. 5 - 5.28 Neurofibromatosis is an autosomal dominant...Ch. 5 - A 2006 genetic study of a large American family...Ch. 5 - 5.30 A experiment examining potential genetic...Ch. 5 - A genetic study of an early onset form of heart...Ch. 5 - In experiments published in 1918 that sought to...Ch. 5 - DNA sequence for 10 individuals are Identify the...Ch. 5 - 5.34 The accompanying pedigree below shows a...Ch. 5 - 5.35 Based on previous family studies, an...Ch. 5 - Divide a clean sheet of paper into four quadrant...Ch. 5 - 5.37 For six genes known to be linked on chromosme...
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