Interpretation:
The
Concept introduction:
The nucleophilic substitutions in which a nucleophile replaces a leaving group are known as
These reactions are unimolecular as the
Polar protic solvents suit
In this reaction, if the concentration of substrate increases, it results in an increase in the rate of reaction.
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Chapter 6 Solutions
ORGANIC CHEMISTRY (LL) W/WILEYPLUS NEXT
- Consider an E2 reaction between (2-bromoethyl)cyclohexane and base potassium tert-butoxide. Describe the rate of elimination when each of the following changes occurred: (i) The base is changed to sodium hydroxide. (ii) The halogen atom of alkyl halide is replaced by chlorine.arrow_forward3. (a) In the following reaction scheme, identify the missing reagent or reagent combination in each step, a-e. b,c Me Me OEt Me OEt Me Me Me NH NH2 Me Me Me Mearrow_forward4. Predict the major product of the following reactions. NBS (a) 0°C Na,Cr,07 H,SO, H,0 (b) он H,SO4 CH,OH (d) heat Brarrow_forward
- In an SN2 reaction between 2-chlorobutane and iodide ion, what happens to the rate of the reaction if: (a) the concentration of 2-chlorobutane is doubled? (b) the concentration of iodide is doubled?arrow_forwardProvide the mechanism for the following reaction (1) PhMgBr (2 equiv) (2) H3O+ workup OHarrow_forwardPredict the products for the following reaction (1,2- and 1,4- addition) and propose a mechanism that explains the formation of each product. (1) (2) HCI + (3) (4)arrow_forward
- Which will produce the best yield of the Zaitsev alkene? O A B (B) (C) (D) Br Br Br Br NaOH NaOH H₂O KOC(CH3)3arrow_forward9. (a) Under certain conditions, the reaction of 0.5 M 1-bromobutane with 1.0 M sodium methoxide forms 1-methoxybutane at a rate of 0.05 mol/L per second. What would be the rate if 0.1 M 1-bromobutane and 2.0 M NaOCH3 were used? (b) Consider the reaction of 1-bromobutane with a large excess of ammonia (NH3). Draw the reactants, the transition state, and the products. Note that the initial product is the salt of an amine (RNH* Br) which is deprotonated by the excess ammonia to give the amine. (c) Show another SN2 reaction using a different combination of an alkoxide and an alkyl bromide that also produces 1-methoxybutane.arrow_forward• H2O Based on the reaction above, (a) Outline the reaction mechanism. (b) Sketch the energy diagram. (c) Give the rate equation. (d) Explain what happens to the reaction rate if: The leaving group is changed to I. (0) (a) The solvent is changed to DMF. The alkyl halide is changed to (v) The concentration of the solvent is increased by five-fold answer with proper justification and with good explanationarrow_forward
- The rate of acetolysis of one of the molecules shown below is 2 x 106 times faster than the other. Predict which molecule reacts the fastest and give a brief explanation to account for this observation. H -N Pr (3) (4) Harrow_forward7.53 Write a sequence of steps depicting the mechanisms of each of the following reactions. Use curved arrows to show electron flow. H+ (a) ОН ОН (b) H2SO4. heat ОН KHSO4 (c) 170°Carrow_forward58. What is the major product of this reaction? Br₂ H3O+ (A) (C) (A) 59. What is the product of this reaction after neutralization? (B) (C) Br or Br (D) HN-CH3 C -CH3 (B) (D) NH₂ Br CH3 N-CH3 HN-CH₂ H3O H₂O Br (C) (A) HO (B) 61. Which conversion is energetically favorable? ok-ob H bi (D) bi - سمه ? (A) (D) ia 62. What starting material will genera product with the given reaction s 1. NaOEt in ethanol HO 2 HO 요. 2. 3. H₂0, H₂O, heat OH OEt 63. What is the monomeric ur polyhydroxy- biodegradab (A) A (C)arrow_forward
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