WHAT IS LIFE ACHIEVE ACCESS ONLY >I<
WHAT IS LIFE ACHIEVE ACCESS ONLY >I<
5th Edition
ISBN: 9781319487317
Author: PHELAN
Publisher: INTER MAC
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Chapter 6, Problem 6SA
Summary Introduction

To review:

Why mRNA moves to the cytoplasm after it is synthesized.

Introduction:

The ribosomes are the site of protein synthesis, and the mRNA must reach them.

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Some genes have the genetic code responsible for coding more than one protein based on the process of mRNA splicing in the nucleus of the eukaryotic cell. Select one: True False
Cystic Fibrosis is a genetically heritable disease caused by the loss of the chloride channel, CFTR. Studies of this gene have found that the Gene includes 250,000bp in the DNA. Scientists found that the mRNA had 6,500 nucleotides, and the final protein had 1480 amino acids. How much of the mRNA is untranslated? How much of the RNA that is produced does not leave the nucleus? One of the mutations that results in a disease phenotype can be easily identified because the mutation results in a much longer mRNA then normal. Where would you look for this mutation? What might this mutation have affected?
Imagine you are going to label a gene associated with apoptosis in Symbiodiniaceae with a Yellow Fluorescent Protein (YFP). To generate the YFP, you know the pre-MRNA looks as follows: Unspliced YFP premature mRNA Сap 5' UTR Exon 1 Intron Exon 2 Intron Exon 3 3' UTR Poly-A tail If Exon 2 is also required for mRNA stability, what can be predicted from the possible spliced alternative isoforms formed? One of the isoforms will not have a poly-A tail O The alternative splicing of YFP pre-MRNA prevents 5'-capping The MRNA isoform without Exon 2 will be degraded faster than the other isoform Exon 2 will be added to isoform B later to correct the mistake in splicing The protein translated from one of the mRNA isoforms will possess an additional functional domain
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