Biochemistry: The Molecular Basis of Life
Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 7, Problem 23RQ
Summary Introduction

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The structure of chondroitin sulfate and proteoglycans to prove the analogy that it acts like a fishnet by letting smaller molecules pass through it and restricting the larger ones.

Introduction:

Proteoglycans are the molecules that have high carbohydrate content. These are either present on the surface of the cell or are secreted in the extracellular matrix. These molecules have GAG (glucosaminoglycans) chains, which are linked to the core proteins. The linkage formed between these two is the N- and O-glycosidic linkage.

Chondroitin sulfate is a sulfated-GAG having glucuronic acid and N-acetylgalactosamine as the alternating sugars present in the chain.

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