EBK FUNDAMENTALS OF BIOSTATISTICS
8th Edition
ISBN: 9780101123402
Author: Rosner
Publisher: YUZU
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Chapter 8, Problem 59P
To determine
Report the p-value for the testing of the mean difference between the two genotypes.
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Age-related macular degeneration (AMD) is a common eye disease among the elderly that can lead to partial or total loss of vision. It is well known that smoking and excessive weight tend to be associated with higher incidence rates of AMD. More recently, however, several genes have been found to
be associated with AMD as well. One gene that has been considered is the Y402H gene (RS 1061170). There are three genotypes for the Y402H gene-TT, TC, and CC. Suppose the relationship between AMD and the Y402H genotype is as follows.
Association between Y402H genotype and
prevalence of AMD in a high-risk
population
Y402H
TT (wild type)
TC
CC
Total
USE SALT
AMD = yes
39
118
120
277
AMD = no
378
528
276
1,182
(a) What is the relative risk for AMD for the CC genotype compared with the TT genotype? (Round your answer to two decimal places.)
(b) One issue is whether the Y402H gene is in Hardy-Weinberg equilibrium (HWE). For a gene to be in HWE, its two alleles must assort…
The recessive mutation bg (beige) in mice results in a decrease in the activity of natural killer
cells in homozygous mutant mice. You test the hypothesis that this cell type plays an important
role in rejection of tumor cells (derived from a tumor induced in an isogenic animal) by injecting
animals with genotypes bg/bg or bg/+ with 106 cells and measuring the time required for the
development of a palpable tumor in each animal. You obtain the following data:
Time to tumor development (days)
Genotype
28, 51, 47, 80
14, 35, 17, 37, 16
3. What is the most appropriate statistical approach to test the hypothesis?
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b. t-test for unpaired samples
C. ANOVA
d. Mann-Whitney U test
e. Kruskal-Wallis test
4. Is there a significant difference in tumor latency between the two groups?
bg/+
bg/bg
Kuru is a prion disease of the Fore people of highland New Guinea. It was once transmitted by the consumption of deceased relatives at mortuary feasts, a ritual that was ended by about 1960. Using archived tissue samples, Mead et al. (2009) investigated genetic variants that might confer resistance to kuru. The data in the accompanying table are genotypes at codon 129 of the prion protein gene of young and elderly individuals all having the disease. Since the elderly individuals have survived long exposure to kuru, unusually common genotypes in this group might indicate resistant genotypes.
b) Test whether genotype frequencies differ between the two age groups.
Provide your answer below.
(Your answer should include 1) null and alternative hypothesis, 2) degrees of freedom, 3) calculated chi-square value, 4) critical chi-square value (alpha=0.05) and 5) final biological conclusion)
Chapter 8 Solutions
EBK FUNDAMENTALS OF BIOSTATISTICS
Ch. 8 - Find the lower 2.5th percentile of an F...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...
Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - The mean 1 sd of ln [calcium intake (mg)] among 25...Ch. 8 - Refer to the data in Table 2.13. Table 2.13...Ch. 8 - Refer to the data in Table 2.13. What is the...Ch. 8 - Refer to the data in Table 2.13. Perform the...Ch. 8 - Refer to the data in Table 2.13. What is the...Ch. 8 - Refer to the data in Table 2.13. 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Prob. 69PCh. 8 - An experiment was conducted to examine the...Ch. 8 - An experiment was conducted to examine the...Ch. 8 - An experiment was conducted to examine the...Ch. 8 - Prob. 73PCh. 8 - Prob. 74PCh. 8 - Prob. 75PCh. 8 - Prob. 77PCh. 8 - A study was performed looking at the effect of...Ch. 8 - A study was performed looking at the effect of...Ch. 8 - A study was performed looking at the effect of...Ch. 8 - Prob. 81PCh. 8 - Prob. 82PCh. 8 - Prob. 83PCh. 8 - Tennis elbow is a painful condition that afflicts...Ch. 8 - Prob. 85PCh. 8 - Prob. 86PCh. 8 - Prob. 87PCh. 8 - Prob. 88PCh. 8 - A study compared mean electroretinogram (ERG)...Ch. 8 - A study compared mean electroretinogram (ERG)...Ch. 8 - A study compared mean electroretinogram (ERG)...Ch. 8 - A study compared mean electroretinogram (ERG)...Ch. 8 - A study compared mean electroretinogram (ERG)...Ch. 8 - Prob. 94PCh. 8 - Prob. 95PCh. 8 - Prob. 96PCh. 8 - Prob. 98PCh. 8 - A study was performed to determine the effect of...Ch. 8 - A study was performed to determine the effect of...Ch. 8 - A study was performed to determine the effect of...Ch. 8 - A study was performed to determine the effect of...Ch. 8 - A study is being planned to assess whether a...Ch. 8 - A study is being planned to assess whether a...Ch. 8 - Prob. 105PCh. 8 - Prob. 106PCh. 8 - Left ventricular mass (LVM) is an important risk...Ch. 8 - Left ventricular mass (LVM) is an important risk...Ch. 8 - Prob. 109PCh. 8 - Prob. 110PCh. 8 - Prob. 111PCh. 8 - A study sought to demonstrate that soy beans...Ch. 8 - Prob. 113PCh. 8 - A study sought to demonstrate that soy beans...Ch. 8 - study was recently reported comparing the effects...Ch. 8 - study was recently reported comparing the effects...Ch. 8 - study was recently reported comparing the effects...Ch. 8 - study was recently reported comparing the effects...Ch. 8 - The Diabetes Prevention Study was a randomized...Ch. 8 - Prob. 122PCh. 8 - Prob. 123PCh. 8 - Prob. 124PCh. 8 - Prob. 125PCh. 8 - Prob. 126PCh. 8 - 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