EBK FUNDAMENTALS OF BIOSTATISTICS
8th Edition
ISBN: 9780101123402
Author: Rosner
Publisher: YUZU
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Chapter 8, Problem 91P
A study compared mean electroretinogram (ERG) amplitude of patients with different genetic types of retinitis pigmentosa (RP), a genetic eye disease that often results in blindness. The results shown in Table 8.24 were obtained for ln (ERG amplitude) among patients 18–29 years of age.
Table 8.24 Comparison of mean ln (ERG amplitude) by genetic type among patients with RP
Implement the test in Problem 8.90, and report a p- value (two-tailed).
8.90 What test can be used to compare the variance of ln (ERG amplitude) between patients with dominant vs. recessive RP?
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Retinitis pigmentosa (RP) is a hereditary ocular diseasein which patches of pigment appear on the retina, potentially resulting in substantial vision loss and in somecases complete blindness. An important issue is how fastthe subjects decline. Visual field is an important measureof area of vision, which is measured in degree2. A visualfield area for a normal person is around 11,000 degree2.The longitudinal data in Table 11.29 were provided by anindividual patient.Table 11.29 Longitudinal visual field data forone RP patientTime Visual field area lnVisit (yr) (degree2) (visual field area)1 0 3059 8.032 1 3053 8.023 2 1418 7.264 3 1692 7.435 4 1978 7.596 5 1567 7.367 6 1919 7.568 7 1998 7.609 11 1648 7.4110 13 1721 7.4511 15 1264 7.14mean 6.09 1938 7.532sd 4.97 597 0.280Suppose the rate of change of ln (visual field) is a linearfunction of follow-up time.11.103 Write down a linear regression model that summarizes this relationship.
Retinitis pigmentosa (RP) is a hereditary ocular diseasein which patches of pigment appear on the retina, potentially resulting in substantial vision loss and in somecases complete blindness. An important issue is how fastthe subjects decline. Visual field is an important measureof area of vision, which is measured in degree2. A visualfield area for a normal person is around 11,000 degree2.The longitudinal data in Table 11.29 were provided by anindividual patient.Table 11.29 Longitudinal visual field data forone RP patientTime Visual field area lnVisit (yr) (degree2) (visual field area)1 0 3059 8.032 1 3053 8.023 2 1418 7.264 3 1692 7.435 4 1978 7.596 5 1567 7.367 6 1919 7.568 7 1998 7.609 11 1648 7.4110 13 1721 7.4511 15 1264 7.14mean 6.09 1938 7.532sd 4.97 597 0.280Suppose the rate of change of ln (visual field) is a linearfunction of follow-up time.11.103 Write down a linear regression model that summarizes this relationship.11.104 Fit the regression line using the method of…
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Chapter 8 Solutions
EBK FUNDAMENTALS OF BIOSTATISTICS
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