Becker's World of the Cell (9th Edition)

9th Edition

ISBN: 9780321934925

Author: Jeff Hardin, Gregory Paul Bertoni

Publisher: PEARSON

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Textbook Question

Chapter 9, Problem 9.11PS

Arsenate Poisoning. Arsenate ( HAsO 4 2 − ) is a potent poison to almost all living systems. Among other effects, arsenate is known to uncouple the phosphorylation event from the oxidation of glyceraldehyde-3-phosphate. This uncoupling occurs because the enzyme involved, glyceraldehyde-3-phosphate dehydrogenase, can utilize arsenate instead of inorganic phosphate, forming glycerate-1-arseno-3-phosphate. This product is a highly unstable compound that immediately undergoes nonenzymatic hydrolysis into glycerate-3-phosphate and free arsenate.

(a) In what sense might arsenate be called an uncoupler of substrate-level phosphorylation?

(b) Why is arsenate such a toxic substance for an organism that depends critically on glycolysis to meet its energy needs?

(c) Can you think of other reactions that are likely to be uncoupled by arsenate in the same way as the glyceraldehyde-3-phosphate dehydrogenase reaction?

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Chapter 9, Problem 9.10PS

Chapter 9, Problem 9.12PS

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Chapter 9 Solutions

Becker's World of the Cell (9th Edition)

Ch. 9 - How are catabolic and anabolic pathways similar?...Ch. 9 - Prob. 9.2CC Ch. 9 - Why do oxidation and reduction reactions always...Ch. 9 - How can glucose be oxidized in the absence of...Ch. 9 - In the absence of oxygen, why is it necessary to...Ch. 9 - Prob. 9.6CC Ch. 9 - Prob. 1Q Ch. 9 - Why dont glycolysis (glucose to pyruvate) and...Ch. 9 - Why are the key regulatory enzymes in glycolysis...Ch. 9 - Why do cancer cells carry out high rates of...

Ch. 9 - High-Energy Bonds. When first introduced by Fritz...Ch. 9 - The History of Glycolysis. Following are several...Ch. 9 - Glycolysis in 25 Words or Fewer. Complete each of...Ch. 9 - Energetics of Carbohydrate Utilization. The...Ch. 9 - QUANTITATIVE Glucose Phosphorylation. The direct...Ch. 9 - Ethanol Intoxication and Methanol Toxicity. The...Ch. 9 - Propionate Fermentation. Although lactate and...Ch. 9 - QUANTITATIVE Glycolysis and Gluconeogenesis. As...Ch. 9 - Prob. 9.9PS Ch. 9 - Youve Got Some Explaining to Do. Explain each of...Ch. 9 - Arsenate Poisoning. Arsenate (HAsO42) is a potent...Ch. 9 - Life Without Phosphofructokinase. Many bacteria do...Ch. 9 - Prob. 9.13PS

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