Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Chapter 9, Problem 9.8PS
QUANTITATIVE Glycolysis and Gluconeogenesis. As Figure 9-12 indicates, gluconeogenesis is accomplished by what is essentially the reverse of the glycolytic pathway but with bypass reactions in place of the first, third, and tenth reactions in glycolysis.
- (a) Explain why it is not possible to accomplish gluconeogenesis by a simple reversal of all the reactions in glycolysis.
- (b) Write an overall reaction for gluconeogenesis that is comparable to Reaction 9-16 for glycolysis.
- (c) Explain why gluconeogenesis requires the input of six molecules of nucleoside triphosphates (four ATPs and two GTPs) per molecule of glucose synthesized, whereas glycolysis yields only two molecules of ATP per molecule of glucose.
- (d) Assuming concentrations of ATP, ADP, and Pi are such that ΔG′ for the hydrolysis of ATP is about −10 kcal/mol, what is the approximate ΔG′ value for the overall reaction for gluconeogenesis that you wrote in part b?
- (e) With all of the enzymes for glycolysis and gluconeogenesis present in a liver cell, how does the cell “know” whether it should be synthesizing or catabolizing glucose at any given time?
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Chapter 9 Solutions
Becker's World of the Cell (9th Edition)
Ch. 9 - How are catabolic and anabolic pathways similar?...Ch. 9 - Prob. 9.2CCCh. 9 - Why do oxidation and reduction reactions always...Ch. 9 - How can glucose be oxidized in the absence of...Ch. 9 - In the absence of oxygen, why is it necessary to...Ch. 9 - Prob. 9.6CCCh. 9 - Prob. 1QCh. 9 - Why dont glycolysis (glucose to pyruvate) and...Ch. 9 - Why are the key regulatory enzymes in glycolysis...Ch. 9 - Why do cancer cells carry out high rates of...
Ch. 9 - High-Energy Bonds. When first introduced by Fritz...Ch. 9 - The History of Glycolysis. Following are several...Ch. 9 - Glycolysis in 25 Words or Fewer. Complete each of...Ch. 9 - Energetics of Carbohydrate Utilization. The...Ch. 9 - QUANTITATIVE Glucose Phosphorylation. The direct...Ch. 9 - Ethanol Intoxication and Methanol Toxicity. The...Ch. 9 - Propionate Fermentation. Although lactate and...Ch. 9 - QUANTITATIVE Glycolysis and Gluconeogenesis. As...Ch. 9 - Prob. 9.9PSCh. 9 - Youve Got Some Explaining to Do. Explain each of...Ch. 9 - Arsenate Poisoning. Arsenate (HAsO42) is a potent...Ch. 9 - Life Without Phosphofructokinase. Many bacteria do...Ch. 9 - Prob. 9.13PS
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