The article “Cellulose Acetate Microspheres Prepared by O/W Emulsification and Solvent Evaporation Method” (K. Soppinmath, A Kulkarni, et al., Journal of Microncapsulation, 2001:811–817) describes a study of the effects of the concentrations of polyvinyl alcohol (PVAL) and dichloromethane (DCM) on the encapsulation efficiency in a process that produces microspheres containing the drug ibuprofen. There were three concentrations of PVAL (measured in units of % w/v) and three of DCM (in ml.). The results presented in the following table are consistent with the means and standard deviations presented in the article.
- a. Construct an ANOVA table. You may give
ranges for the P-values. - b. Discuss the relationships among PVAL concentration, DCM concentration, and encapsulation efficiency.
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