7. Later, we will cover mass spectrometry, and will likely also mention a combined analytical technique called GC- MS (gas chromatography-mass spectrometry). Briefly, but clearly, explain how GC-MS would be better at solving the "caffeine crime" compared to simple TLC. What information does GC-MS provide that TLC does not?

7. Later, we will cover mass spectrometry, and will likely also mention a combined analytical technique called GC- MS (gas chromatography-mass spectrometry). Briefly, but clearly, explain how GC-MS would be better at solving the "caffeine crime" compared to simple TLC. What information does GC-MS provide that TLC does not?

Principles of Instrumental Analysis

7th Edition

ISBN:9781305577213

Author:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Publisher:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Chapter28: High-performance Liquid Chromatography

Section: Chapter Questions

Problem 28.17QAP: Mass spectrometry is an extremely versatile detection system for GC. However, interfacing an HPLC...

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As1...If a TLC plate shows only one spot with an Rf value of 0.98, does this mean the sample is pure? Briefly explain why or why not.
If a TLC was run in a solvent system that caused all the spots to show up at the baseline, how could the system be adjusted so that Rf values could be determined?
How would you discuss method of separation and identification of compounds in TLC?
A student performs a TLC experiment and at the end of the experiment, sees no spots other than the initial spot. What does this mean, and what should the student do to fix the problem?
An unknown mixture was analyzed with TLC on a silica gel plate. Development gave two spots with Rf values of 1.0 and 0.0 respectively.a) Can you say for sure how many compounds are present in the mixture? If so, how many are there? Explain. b) If not, what additional TLC experiment(s) might be performed to determine how many components are present? Explain.
You will run a TLC plate after the CC placing in one spot the original sample of pigments, one spot from the yellow band and one from the green band. Draw a picture of what you expect to observe after running the TLC plate. Explain.
There were 2 spots on the TLC that did not match up with any of the standards. What were the Rf values of these spots? Identify what these chemical species might be and draw their structures. Solvent was 3:1:1 n-butanol/acetic acid/water. First plate is TLC plate 1. Second plate is TLC plate 2.
1. a compound has an Rf value of 0.97 diethyl ether but an Rf value of 0.045 in cyclohexane. Suggest a couple (at least three) solvent (solvents), or solvent system (systems), that might be better suited for this particular compound. 2. suppose your TLC plate shows only one spot at an Rf value of 0.015 (essentially it does not move). Does this mean that your sample is 100% pure? Explain your answer. 3. suppose your TLC plate shows only one spot at an Rf value of 0.98 (essentially with the solvent front). Does this mean that your sample is 100% pure? Explain your answer.
So I completing a lab report and one of the sections is on TLC analysis. In the experiment, the TLC plate was submerged in toluene ethylacetate and had spots of cinnamon leaf oil, cinnamon aldehyde, and cinnamon bark oil. 9 spots total were seen under the UV light, but different spots appeared following a vanillin stain. Why is this so and what does this mean?
Mass spectrometry is an extremely versatile detection system for GC. However, interfacing an HPLC system to a mass spectrometer is a much more difficult task. Describe the major reasons why it is more difficult to combine HPLC with mass spectrometry than it is to combine GC with mass spectrometry.
Identify the statement that correctly interprets this TLC analysis of a recrystallized sample of acetaminophen produced following the procedure outlined in Experiment 5: The TLC of an individuals purified acetaminophen showed two spots. One spot had an Rf identical to that of pure acetaminophen. This spot was also larger and darker than the second spot. The Rf of the second spot was very close to the Rf of pure 4-aminophenol. a) The two spots evident in my TLC analysis indicate my sample is a mixture. Since each spot has an Rf value that is close to the Rf of one of the authentic materials tested, I can conclude my sample is a mixture of acetaminophen and 4-aminophenol. The large size of the spot with an Rf nearly identical to authentic acetaminophen indicates my sample is mostly 4-aminophenol. b)I can conclude from this evidence that my sample is a mixture of acetaminophen and 4-aminophenol because the Rf of each of the spots is nearly identical to one of the authentic…
For a reverse phase TLC separation, which of the following molecules will elute first?a. 1 b. 2 c. 3