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A: Answer
Explain with specific examples how oncogenic receptors would promote cellular proliferation in the absence of external growth factors
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- Explain the activation of the protein kinase, c-raf, in response to growth factor receptor activationGiven the following scenario, indicate if this will ‘promote’ or ‘prevent’ cancer development: An over-expression of Bcl-2Antibodies have two identical antigen-binding sites. Remarkably, antibodies to the extracellular parts of growth-factor receptors often lead to the same cellular effects as does exposure to growth factors. Explain this observation
- Describe an example of a pathological condition that results in mutants genes that control expression of the inducer or components of its pathway. Inducing Factor Signal Transduction Pathway and Components Developmental Functions and Target Cell/Tissue Associated Pathologies TGF-B FGF Hedgehog EGFIdentify the two general functions of the proteins encoded bytumor-suppressor genes.Chemotherapeutic agents can promote apoptosis in cancer cells by these mechanisms except; Group of answer choices Downregulating MCL1 expression Increasing BCL-2 expression Increased p53 expression Increased BIM (BH-3) expression
- What is the difference between Prima-1 and nutlins in the way they would fight cancer?Explain the NF-KB pathway and the interaction between it and COX and interleukins in the inflammatory repsonse process in regards to adenocarcinoma tumours colon cancer.Which of the following describes the role typical proto-oncogenes have when they are expressed in cells that are not cancerous
- Discuss the family of nuclear hormone receptors and explain how ligand binding to such a receptor can result in changes in gene expressionExplain why in cells that are genetically NF1–/–, basal levels of GTP-bound activated Ras are higher than normal and respond to growth factor stimulation by increasing rapidly to far higher levels.''In the cellular regulatory pathways that controlcell growth and proliferation, the products of oncogenesare stimulatory components and the products of tumorsuppressor genes are inhibitory components.'' 'Is this statement true? Explain why or why not.