Part 1: Synthesis of Ligand. In this experiment you prepare the chiral ligand 4 by first converting the salt 2 to its free amine 2' then condensing it with aldehyde 3a to give bis-imine 4. t-Bu t-Bu „NH3 O2C HO NH2 OH i) K2CO3 ethanol, reflux "NH3 O2C "., “NH2 OH OH t-Bu t-Bu 2 2' t-Bu t-Bu За 1. NMR analysis of compound 4 is not performed. By comparing the structures of free amine 2' and aldehyde 3a with the bis-imine 4 indicate which two signals in the 'H-NMR (of 4) would be most useful to confirm its formation? Ensure you explain your answer and use appropriately labelled diagrams to illustrate. (Hint. Which chemical environments change the most when forming 4 from 2' and 3a)

Part 1: Synthesis of Ligand. In this experiment you prepare the chiral ligand 4 by first converting the salt 2 to its free amine 2' then condensing it with aldehyde 3a to give bis-imine 4. t-Bu t-Bu „NH3 O2C HO NH2 OH i) K2CO3 ethanol, reflux "NH3 O2C "., “NH2 OH OH t-Bu t-Bu 2 2' t-Bu t-Bu За 1. NMR analysis of compound 4 is not performed. By comparing the structures of free amine 2' and aldehyde 3a with the bis-imine 4 indicate which two signals in the 'H-NMR (of 4) would be most useful to confirm its formation? Ensure you explain your answer and use appropriately labelled diagrams to illustrate. (Hint. Which chemical environments change the most when forming 4 from 2' and 3a)

Principles of Instrumental Analysis

7th Edition

ISBN:9781305577213

Author:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Publisher:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Chapter14: Applications Of Ultraviolet-visible Molecular Absorption Spectrometry

Section: Chapter Questions

Problem 14.7QAP: A 3.03-g petroleum specimen was decomposed by wet ashing and subsequently diluted to 500 mL in a...

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Describe main features of the evidence of M-CºC characterization and corresponding techniques of this complex (COCL(PPh3)2-III(CF3)2)...?
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Mention 3 typical organic complexing agents in the environment and describe in which environments (in the widest sense) they are found and which elements are particularly taken up.
19. The association constant of protein X for ligand Y is: 100 micromolar. At what concentration of ligand is half fo the protein bound?
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The red color of soil is often due to the presence of iron. Metal ions are extracted from soil by stirring the soil in acid and then filtering the solution. One method for the analysis of Fe2+ is to form the highly colored Fe2+–thioglycolic acid complex. The complex absorbs strongly at 535 nm. Calibration standards of 1.00, 2.00, 3.00, 4.00, and 5.00 ppm are prepared by transferring appropriate amounts of a 10.0 ppm working solution of Fe2+ into separate 50-mL volumetric flasks, each of which contains 5 mL of thioglycolic acid, 2 mL of 20% w/v ammonium citrate, and 5 mL of 0.22 M NH3. After diluting to volume and mixing, the absorbances of the standards are measured. a)What is the effect on the reported concentration of iron in the sample if there is a trace impurity of Fe2+in the ammonium citrate?
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