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Questions 4 through 6 refer to the following hypothetical pathway in which substance A is converted to substance C by enzymes 1 and 2. Substance B is the intermediate produced in this pathway: a. If the first individual in Question 4 married the second individual, would their children be able to convert substance A into substance C? b. Suppose each of the adults mentioned in part a was heterozygous for an autosomal dominant mutation that prevents any enzyme function. List the phenotypes of their children with respect to compounds A, B, and C. (Would the compound be in excess, not present, and so on?)

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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Section
BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 10, Problem 5QP
Textbook Problem
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Questions 4 through 6 refer to the following hypothetical pathway in which substance A is converted to substance C by enzymes 1 and 2. Substance B is the intermediate produced in this pathway:

Chapter 10, Problem 5QP, Questions 4 through 6 refer to the following hypothetical pathway in which substance A is converted

a. If the first individual in Question 4 married the second individual, would their children be able to convert substance A into substance C?

b. Suppose each of the adults mentioned in part a was heterozygous for an autosomal dominant mutation that prevents any enzyme function. List the phenotypes of their children with respect to compounds A, B, and C. (Would the compound be in excess, not present, and so on?)

a.

Summary Introduction

To explain: Whether children will be able to convert substance A into substance C.

Introduction: Metabolic pathways are catalyzed by using enzymes. These enzymes are synthesized based on the information provided by the genes specified for them. Any change in these genes can hinder the synthesis of these enzymes or may lead to the synthesis of faulty enzymes. Null mutation makes the enzymes non-functional or makes them non-existent.

Explanation of Solution

Assumptions: E shows normal allele for enzyme 1 and e shows a null mutation in enzyme 1 (for an individual in problem 4 a.)

D shows normal allele for enzyme 2 and d shows a null mutation in enzyme 2 (for the individual in problem 4 b.)

Hence, eeDD shows the genotype of person 1 (from problem 4 a.), who is homozygous for the null mutation of enzyme 1. Gametes from this person will have the genotype as eD.

EEdd shows the genotype of person 2 (from problem 4 b.), who is homozygous for the null mutation of enzyme 2...

b.

Summary Introduction

To explain: The possible phenotypes with respect to compounds A, B, and C in children born from individuals mentioned if both the individuals were heterozygous for an autosomal dominant mutation that prevents the function of an enzyme.

Introduction: Metabolic pathways are catalyzed by using enzymes. These enzymes are synthesized based on the information provided by the genes specified for them. Any change in these genes can hinder the synthesis of these enzymes or may lead to the synthesis of faulty enzymes. Null mutation makes the enzymes non-functional or makes them non-existent.

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