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Transcriptional regulators are proteins that bind to promoters (the 5′-flanking regions of genes) to regulate their transcription. Assume that a particular transcription regulator normally promotes transcription of gene X, a transport protein. If a mutation makes this regulator gene nonfunctional, would the resulting phenotype be similar to a mutation in gene X itself? Why or why not?

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Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052

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BuyFindarrow_forward

Human Heredity: Principles and Iss...

11th Edition
Michael Cummings
Publisher: Cengage Learning
ISBN: 9781305251052
Chapter 10, Problem 21QP
Textbook Problem
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Transcriptional regulators are proteins that bind to promoters (the 5′-flanking regions of genes) to regulate their transcription. Assume that a particular transcription regulator normally promotes transcription of gene X, a transport protein. If a mutation makes this regulator gene nonfunctional, would the resulting phenotype be similar to a mutation in gene X itself? Why or why not?

Summary Introduction

To explain: Whether the resulting phenotype of a gene X will be similar to a mutation in gene X itself or not, if there is a mutation in its transcriptional factor that makes the factor nonfunctional.

Introduction: Transcriptional regulators perform the function of controlling the expression or nonexpression of a gene. These are the protein molecules that bind towards the promoter region in a gene. A regulator either promotes or reduces the expression of the gene. Mutation in the regulator protein can cause over-expression or under-expression of a particular gene.

Explanation of Solution

Exon region in any gene represents its promoter sequence. The promoter region of a gene controls the translation of the gene and thus the synthesis of protein due to that particular gene. Regulator molecules either increases or reduces the expression of a gene. Change or any mutation in the regulator molecule can extremely increase or reduce the expression of a gene...

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